Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis

Details

• Personal Author:
  Arvapalli R ; Asano S ; Blough ER ; Fankenhanel E ; Ma JY ; Maheshwari M ; Manne NDPK ; Nepal N ; Rice KM ; Rogers S ; Selvaraj V ; Shokuhfar T
• Description:
  The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay. [Description provided by NIOSH]
• Subjects:
  Animals Blood Laboratories Morbidity Mortality Occupational Health Safety
• Keywords:
  Author Keywords: Cerium Oxide Nanoparticles Blood-cells Cerium-compounds Diseases In-vivo-study Laboratory-animals LPS Morbidity-rates Mortality-rates MTT Nanotechnology Physiological-factors Physiology Proteins Raw 264.7 Sepsis Sprague Dawley Rat

  More +
• ISSN:
  2352-3409
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  105-115
• Volume:
  4
• NIOSHTIC Number:
  nn:20046325
• Citation:
  Data Brief 2015 Sep; 4:105-115
• Contact Point Address:
  E.R. Blough, Center for Diagnostic Nanosystems, Robert C. Byrd Biotechnology Science Center, Marshall University, 1700 3rd Ave., Huntington, WV 25755-1090
• Email:
  blough@marshall.edu
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3)
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  True
• Source Full Name:
  Data in Brief
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:025019bead8cea74040d4761478cf920bfcc4d3cfecadabb7ca6ea1a62f897d9ece96fd634e6994e02e6d11f6950255d9be66d36c35412f2cb3311093ece390a
• Download URL:
  https://stacks.cdc.gov/view/cdc/201422/cdc_201422_DS1.pdf
• File Type:
  [PDF - 375.20 KB ]