Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies

Details

• Personal Author:
  B'hymer C ; Mathias PI
• Description:
  This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research. [Description provided by NIOSH]
• Subjects:
  Acids Biomarkers Chemistry Chromatography Energy Metabolism Environmental Exposure Occupational Health Risk Assessment Risk Factors Safety Urine

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• Keywords:
  Author Keywords: Internal Exposure Biological Materials Chemical Composition Chemical Properties Environmental Exposure Exposure Levels Fluids Liquid Chromatography Mass Spectrometry Mercapturic Acid Metabolism Molecular Structure Risk Factors Toxicant Metabolism Urinalysis Urinary Biomarker Urine Chemistry

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• ISSN:
  1354-750X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-315
• Volume:
  21
• Issue:
  4
• NIOSHTIC Number:
  nn:20047660
• Citation:
  Biomarkers 2016 Jun; 21(4):293-315
• Contact Point Address:
  Patricia I. Mathias, National Institute for Occupational Safety and Health, Division of Applied Science and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  pmathias@cdc.gov
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Services
• Peer Reviewed:
  True
• Source Full Name:
  Biomarkers
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6e08029881140f9fd519eb08530cb5454047153fd4658896afb5641e17c01be15d03165c7613518d103d10a5e90a2caf0d95c02e8d1510e585f462cd1e3896a6
• Download URL:
  https://stacks.cdc.gov/view/cdc/202671/cdc_202671_DS1.pdf
• File Type:
  [PDF - 826.55 KB ]