Microfluidic columns with nanotechnology-enabled stationary phases for gas chromatography

Details

• Personal Author:
  Shakeel H
• Description:
  Advances in micro-electro-mechanical-systems (MEMS) along with nanotechnology based methods have enabled the miniaturization of analytical chemistry instrumentation. The broader aim is to provide a portable, low-cost, and low-power platform for the real-time detection and identification of organic compounds in a wide variety of applications. A benchtop gas chromatography (GC) system is considered a gold standard for chemical analysis by analytical chemists. Similarly, miniaturization of key GC components (preconcentrator, separation column, detector, and pumps) using micro- and nanotechnology based techniques is an on-going research field. This dissertation specifically deals with the design, fabrication, coating, and chromatographic testing of microfabricated separation columns for GC. This work can be broadly categorized into three research areas: design and development of new column designs, introduction of new stationary phases and the development of novel fabrication methodologies for integrating functionalized thin-film into microchannels for chromatographic separations. As a part of this research, two high performance new micro column designs namely width-modulated and high-density semi-packed columns are introduced for the first time. Similarly, two new types of functionalized stationary phases are also demonstrated i.e. a highly stable and homogenous silica nanoparticles coating deposited using a layer-by-layer self-assembly scheme and a highly conformal functionalized thin aluminum oxide film deposited using atomic layer deposition. Moreover, novel thin-film patterning methods using different microfabrication technologies are also demonstrated for high-aspect ratio multicapillary and semi-packed columns. [Description provided by NIOSH]
• Subjects:
  Chemistry Environmental Health Food Handling Food Industry Occupational Health Pharmacies Safety
• Keywords:
  Author Keywords: Micro Gas Chromatography Biomedical-engineering Chemical-analysis Chemical-composition Chemical-properties Environmental-factors Food-processing Gas-chromatography MEMS Columns Monitoring-systems Nanoparticles Nanotechnology Organic-compounds Pharmaceutical-industry Separation Columns Stationary Phases

  More +
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Dissertation
• Place as Subject:
  OSHA Region 3 ; Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-130
• NIOSHTIC Number:
  nn:20047248
• Citation:
  Blacksburg, Virginia: Virginia Polytechnic Institute and State University, 2015 Jan; :1-130
• Federal Fiscal Year:
  2015
• Performing Organization:
  Virginia Polytechnic Institute and State University
• Peer Reviewed:
  False
• Start Date:
  20120701
• Source Full Name:
  Microfluidic columns with nanotechnology-enabled stationary phases for gas chromatography
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:192061f87156872e2b403286283e78beb4ec011144d904ed4885dc0261375fec9ed84920262dc04144af8f2d178fafe2611b16bf85bed226963a0f271b01ee45
• Download URL:
  https://stacks.cdc.gov/view/cdc/202394/cdc_202394_DS1.pdf
• File Type:
  [PDF - 6.71 MB ]