Urinary phthalate metabolite concentrations and blood glucose levels during pregnancy

Details

• Personal Author:
  Calafat, Antonia M. ; Carabin H ; Cowan L ; Goodman JR ; Peck JD ; Robledo CA ; Stoner J
• Description:
  PURPOSE: To examine associations between phthalate metabolite urinary concentrations during early pregnancy and blood glucose levels obtained at the time of screening for gestational diabetes mellitus (GDM). METHODS: Upon initiation of prenatal care, women with a mean gestational age of 12.8 weeks were recruited for a study of environmental chemical exposures (n = 110) and provided a spot urinary specimen. Blood glucose concentrations (mg/dl) were obtained from the electronic medical record for those patients who did not experience a pregnancy loss and did not transfer care to another facility prior to glucose screening (n = 72). Urinary concentrations of nine phthalate metabolites and creatinine were measured at the US Centers for Disease Control and Prevention. Associations between tertiles of phthalate metabolites concentrations and blood glucose levels were estimated using linear regression. RESULTS: Compared to pregnant women in the lowest concentration tertile, women with the highest urinary concentrations (= 3 rd tertile) of mono-iso-butyl phthalate (tertile: = 15.3 ug/l, beta = -18.3, 95% CI: -35.4, -1.2) and monobenzyl phthalate (tertile: = 30.3 ug/l, beta = -17.3, 95% CI: -34.1, -0.4) had lower blood glucose levels at the time of GDM screening after adjustment for urinary creatinine and demographic covariates. CONCLUSION: Because maternal glucose levels increase during pregnancy to provide adequate nutrition for fetal growth and development, these findings may have implications for fetal health. However, given the limitations of our study, findings should be interpreted cautiously. [Description provided by NIOSH]
• Subjects:
  Energy Metabolism Occupational Health Phthalic Acids Pregnancy Safety Urine Women
• Keywords:
  Author Keywords: Phthalate Blood Glucose Humans Metabolism Phthalates Urinalysis
• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Illinois ; Oklahoma ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  324-330
• Volume:
  218
• Issue:
  3
• NIOSHTIC Number:
  nn:20047160
• Citation:
  Int J Hyg Environ Health 2015 May; 218(3):324-330
• Contact Point Address:
  Candace A. Robledo, Department of Biostatistics & Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, 801 NE 13th St., Room 309,Oklahoma City, OK 73104, USA
• Email:
  candace.robledo@unthsc.edu
• CAS Registry Number:
  Mono(2-ethylhexyl) phthalate (CAS RN 4376-20-9) ; Mono-2-ethyl-5-hydroxyhexyl phthalate (CAS RN 40321-99-1) ; Monobenzyl phthalate (CAS RN 2528-16-7) ; Monobutyl phthalate (CAS RN 131-70-4) ; Monoethyl phthalate (CAS RN 2306-33-4) ; Monoisobutyl phthalate (CAS RN 30833-53-5)
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:384c7bb65ff22538b60582fbb7769fd458493c3c1a3148332ad14dac4baec39d5da08313f0c10b8d0cf468b3b331509e06493d0bb5d6fcc2b401204d53854e83
• Download URL:
  https://stacks.cdc.gov/view/cdc/202330/cdc_202330_DS1.pdf
• File Type:
  [PDF - 385.64 KB ]