24-Hour human urine and serum profiles of bisphenol: evidence against significant sublingual absorption of BPA following oral exposure in soup

Details

• Personal Author:
  Churchwell MI ; Doerge DR ; Teeguarden JG ; Twaddle NC
• Description:
  Human exposure to bisphenol A (BPA), a weakly estrogenic monomer used in the manufacture of some plastics and epoxy can liners, is virtually ubiquitous. Extensive first-pass metabolism of orally ingested BPA by gastro-intestinal tract and hepatic tissues restricts human blood concentrations bioactive BPA to less than approximately 0.5% of total BPA approximately picomolar concentrations, even at the upper bounds of human exposure. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, which would bypass first-pass metabolism, could lead to higher BPA blood concentrations, like those reported some human studies, but are likely due to sample contamination. We hypothesized that if absorption through non-metabolizing oral cavity tissues was significant, higher bioavailability, higher serum BPA concentrations, and faster kinetics would result from exposure in soup, compared to prior studies in solid food or capsules. Serum and urine concentrations of BPA, and metabolites, were measured in 10 adult volunteers following ingestion of 30 ug/kg BW d6-BPA in soup. Absorption of BPA was rapid and complete, with an absorption half-life of 0.45 h, and complete urinary elimination by 24 hours post-ingestion. The maximum BPA concentration in serum, 0.43 nM, was <0.3% of total BPA, and occurred 1.6 h after administration. All pharmacokinetic parameters were consistent with those reported in previous oral pharmacokinetic studies in humans and animals. Pharmacokinetic parameters and pharmacokinetic model simulations of the data were inconsistent with absorption through a nonmetabolizing tissue (below 1%). In conclusion, we found clear evidence against, and no evidence for, meaningful absorption through the oral cavity or other non-metabolizing tissues following exposure to BPA in a liquid food. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Energy Metabolism Epoxy Resins Food Contamination Occupational Health Plastics Risk Assessment Risk Factors Safety Urine

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• Keywords:
  Epoxy-compounds Exposure-levels Food-contaminants Gastrointestinal-system Gastrointestinal-system-disorders Metabolism Models Monomers Oral-cavity Risk-factors Urinalysis

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Arkansas ; Ohio ; Oregon ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 6 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  144
• Issue:
  1
• NIOSHTIC Number:
  nn:20047148
• Citation:
  Toxicologist 2015 Mar; 144(1):108
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2015
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  False
• Start Date:
  20120701
• Source Full Name:
  The Toxicologist. Society of Toxicology 54th Annual Meeting and ToxExpo, March 22-26, 2015, San Diego, California
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b75cf8e2c16b42e4591e34a1de8ced59e5a4c802dcde1a93fc987c7d63d977ea436ef2e7cbbf47f66ccb1d86e585df53ac1b7baa862379704fa97ce37337ad2
• Download URL:
  https://stacks.cdc.gov/view/cdc/202321/cdc_202321_DS1.pdf
• File Type:
  [PDF - 221.02 KB ]