24-Hour human urine and serum profiles of bisphenol A following ingestion in soup: individual pharmacokinetic data and demographics

Details

• Personal Author:
  Churchwell MI ; Doerge DR ; Fisher JW ; Seryak LM ; Teeguarden JG ; Twaddle NC ; Yang X
• Description:
  Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 h period in 10 adult male volunteers following ingestion of 30 µg d6-BPA/kg body weight in soup. The pharmacokinetic behavior of BPA and its metabolites in this cohort (rapid absorption, complete elimination, evidence against sublingual absorption) was reported. This Data in Brief article contains the corresponding individual pharmacokinetic data, reports the demographics of the cohort and provides additional details related to the analytical methods employed and is related to: J.G. Teeguarden, N. Twaddle, M.I. Churchwell, X. Yang, J.W. Fisher, L.M. Seryak, D.R. Doerge [2015]. 24-hour human urine and serum profiles of bisphenol A: evidence against sublingual absorption following ingestion in soup. Toxicol Appl Pharmacol 2015 Oct; 288(2):131-142. [Description provided by NIOSH]
• Subjects:
  Digestive System Energy Metabolism Men Occupational Health Risk Assessment Risk Factors Safety Urine
• Keywords:
  Biological-effects Exposure-levels Food Gastrointestinal-system Humans Metabolism Oral-cavity Risk-factors Urinalysis
• ISSN:
  2352-3409
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Ohio ; Oregon ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 6 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  83-86
• Volume:
  4
• NIOSHTIC Number:
  nn:20047151
• Citation:
  Data Brief 2015 Sep; 4:83-86
• Contact Point Address:
  Justin G. Teeguarden, Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352
• Email:
  jt@pnl.gov
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2015
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Data in Brief
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d378efe9aab39d309322a01a15fd26233fbee26a44defa7f7fadae341b8e34b55537fa1943b0896994f49ccbea00ffff4289e2694e4df6f3936b1143a3350ae7
• Download URL:
  https://stacks.cdc.gov/view/cdc/202324/cdc_202324_DS1.pdf
• File Type:
  [PDF - 175.49 KB ]