Human Exposure to Bisphenol A (BPA)

Details

• Personal Author:
  Hauser R ; Marcus M ; Olea N ; Vandenberg LN ; Welshons WV
• Description:
  The plastic monomer and plasticizer bisphenol A (BPA) is one of the highest volume chemicals produced worldwide. BPA is used in the production of polycarbonate plastics and epoxy resins used in many consumer products. Here, we have outlined studies that address the levels of BPA in human tissues and fluids. We have reviewed the few epidemiological studies available that explore biological markers of BPA exposure and human health outcomes. We have examined several studies of levels of BPA released from consumer products as well as the levels measured in wastewater, drinking water, air and dust. Lastly, we have reviewed acute metabolic studies and the information available about BPA metabolism in animal models. The reported levels of BPA in human fluids are higher than the BPA concentrations reported to stimulate molecular endpoints in vitro and appear to be within an order of magnitude of the levels needed to induce effects in animal models. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Energy Metabolism Epidemiology Epoxy Resins Men Occupational Health Plastics Risk Assessment Risk Factors Safety Urine Women

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• Keywords:
  Author Keywords: Serum Bisphenol A Chemicals Children Dental Sealants Disease Epoxy Compounds Epoxy Resins Exposure Limits Fluids Health Effects Humans In Vitro Study Metabolic Study Metabolism Models Polycarbonate Plastic Risk Factors Tissue Culture

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• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; Missouri ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  139-177
• Volume:
  24
• Issue:
  2
• NIOSHTIC Number:
  nn:20059664
• Citation:
  Reprod Toxicol 2007 Aug-Sep; 24(2):139-177
• Contact Point Address:
  Laura N Vandenberg, Tufts University School of Medicine, Sackler School of Graduate Biomedical Sciences, 136 Harrison Avenue, Boston, MA 02111
• Email:
  laura.vandenberg@tufts.edu
• CAS Registry Number:
  Bisphenol A diglycidyl ether (CAS RN 1675-54-3)
• Federal Fiscal Year:
  2007
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad4a371b729152f18ddfd429c1fd88202172bd4cf80dae435c2562fe07272bcbbb3df124e9bf5752d7fb84708e7aee126f19658964102ecbbba5956451b14035
• Download URL:
  https://stacks.cdc.gov/view/cdc/223813/cdc_223813_DS1.pdf
• File Type:
  [PDF - 847.59 KB ]