Immunological studies of experimental coalworkers' pneumoconiosis

Details

• Personal Author:
  Burrell R ; Flaherty DK ; Schreiber JE
• Description:
  A comparative immunological and microbiological study of experimental coalworkers' pneumoconiosis (CWP) was made in rats and mice subjected to long-term exposures of coal-mine dust aerosols. Such aerosols were realistically prepared at a concentration equal to the maximal level of respirable dust permitted by Federal standards and animals were exposed for lengths of time equal to human work contact. Among the factors studied were the production of lgA and lung reactive antibody, lung microflora and changes in pulmonary clearance. Additional experiments were concerned with the effects of passively administered lung antibody on the pulmonary clearance. It was found that both species responded immunologically in a similar manner to humans with CWP in that lgA levels were significantly elevated and lung reactive antibodies were stimulated. Coal-mine dust inhalation had little effect on the pulmonary inactivation of inhaled bacteria, but the concomitant occurrence of passively administered lung reactive antibody seemed to enhance the inactivation. [Description provided by NIOSH]
• Subjects:
  Animals Coal Dust Laboratories Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Coal-dust Laboratory-animals Respirable-dust Respiratory-system-disorders
• ISBN:
  9780080205601
• Publisher:
  Pergamon Press
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; OSHA Region 5 ; West Virginia ; Wisconsin
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20047137
• Citation:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom. Walton WH, ed. Oxford: Pergamon Press, 1977 Jan; 4(Pt 2):519-529
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1977
• Peer Reviewed:
  False
• Part Number:
  2
• Source Full Name:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e8e19e4ac7228f026ef79afdf2951b9a554ab22c18062acde88e945635ef25beaa7295e591051fd43f365a125401c648d7462f51953397bec125302ec7a4667c
• Download URL:
  https://stacks.cdc.gov/view/cdc/202319/cdc_202319_DS1.pdf
• File Type:
  [PDF - 4.84 MB ]