Investigation of alveolar macrophages from rats exposed to coal dust

Details

• Personal Author:
  Barkley ; Bingham E ; Murthy R ; Vassallo C
• Description:
  Rats were exposed to the inhalation of coal dust from either Utah (low prevalence coalworkers' pneumoconiosis (CWP)) or Pennsylvania (high prevalence CWP). Rats were sacrificed, the lungs removed and lavaged to obtain free cells. The number of alveolar macrophages recovered from rats inhaling these two coal dusts (exposures up to 4 months) was not remarkably different from the number recovered from rats inhaling filtered room air. This is in contrast to results obtained after intratracheal intubation of the dust. The capacity of the lavaged cells to phagocytize and kill bacteria decreased after exposure to either dust. The activity of certain enzymes also decreased. [Description provided by NIOSH]
• Subjects:
  Animals Coal Dust Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal-studies Coal-dust Laboratory-animals Lung-function Respirable-dust Respiratory-system-disorders
• ISBN:
  9780080205601
• Publisher:
  Pergamon Press
• Document Type:
  Text
• Funding:
  Grant ; Contract
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20047138
• Citation:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom. Walton WH, ed. Oxford: Pergamon Press, 1977 Jan; 4(Pt 2):543-550
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1977
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  False
• Part Number:
  2
• Start Date:
  19710501
• Source Full Name:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom
• End Date:
  19750731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73810dd76a1199f722c3980e994fe264cfda6137418fdd004888d3fed9dfb32d1b087ec33ca5d769d25306d792aae3717145279375db85fe7cb139ba94dca14e
• Download URL:
  https://stacks.cdc.gov/view/cdc/202320/cdc_202320_DS1.pdf
• File Type:
  [PDF - 2.98 MB ]