Pulmonary inflammatory effects of source-oriented particulate matter from California's San Joaquin Valley

Details

• Personal Author:
  Bein KJ ; Carosino CM ; Pinkerton KE ; Plummer LE ; Smiley-Jewell S ; Wexler AS ; Willits N ; Zhao-Y
• Description:
  The EPA regulates ambient particulate matter (PM) because substantial associations have been established between PM and health impacts. Presently, regulatory compliance involves broad control of PM emission sources based on mass concentration rather than chemical composition, although PM toxicity is likely to vary depending upon PM physicochemical properties. The overall objective of this study was to help inform source-specific PM emission control regulations. For the first time, source-oriented PM was collected from the atmosphere in Fresno, CA, onto 38 source/size substrates. Mice were exposed via oropharyngeal aspiration to equivalent mass doses [50 microg] of two size fractions: ultrafine (Dp < 0.17 microm) and submicron fine (0.17 < Dp < 1 microm) during summer and winter seasons. At 24 h post-exposure, cellular and biochemical indicators of pulmonary inflammation were evaluated in the bronchoalveolar lavage fluid. Significant inflammatory responses were elicited by vehicle, regional background, and cooking PM sources that were dependent on season and particle size. This is the first study of sourceoriented toxicity of atmospheric PM and supports source-specific emissions control strategies. [Description provided by NIOSH]
• Subjects:
  Air Pollution Environmental Exposure Environmental Pollution Immune System Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Air Pollution Author Keywords: Air Pollution Emission Sources Environmental Pollution Exposure Assessment Fresno Immune Reaction Lung Irritants Particulates PM Pulmonary Function Respiratory System Disorders Submicron Fine Ultrafine

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• ISSN:
  1352-2310
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  174-181
• Volume:
  119
• NIOSHTIC Number:
  nn:20047024
• Citation:
  Atmos Environ 2015 Oct; 119:174-181
• Contact Point Address:
  Kent E. Pinkerton, University of California, Davis, Center for Health and the Environment, Bldg 3792, Old Davis Road, Davis, CA, 95616, USA
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Atmospheric Environment
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1cfa86b6aec02c1d124df6ad18cf427c1a1d9c76c8cc6ff8293aa6de2e00e163f6f8c7fcfda43c846e97e061293b84f415728a82c0056dd1d6edc03959d69892
• Download URL:
  https://stacks.cdc.gov/view/cdc/202257/cdc_202257_DS1.pdf
• File Type:
  [PDF - 1.36 MB ]