Recent developments in paper-based microfluidic devices

Details

• Personal Author:
  Adkins JA ; Cate DM ; Henry CS ; Mettakoonpitak J
• Description:
  Paper has been used as a substrate material in analytical testing for centuries, with scientific reports dating back to the early 1800s with litmus paper. As a substrate material, paper (and related porous hydrophilic materials) has many unique advantages over traditional device materials including power-free fluid transport via capillary action, a high surface area to volume ratio that improves detection limits for colorimetric methods, and the ability to store reagents in active form within the fiber network. As a result of these benefits, paper has been used in applications ranging from spot tests for metals and paper chromatography to lateral flow immunoassays. Paper as a substrate material for microf luidic assays was largely ignored, however, until 2007 when Martinez et al. reported the first microfluidic paper-based analytical device (iPAD) for chemical analysis. The unique aspect of this seminal work lies in the use of a hydrophobic (photoresist in this case) patterning reagent to define hydrophilic flow channels for directing sample from an inlet to a defined location for subsequent analysis. This simple yet elegant development led many to realize paper as a substrate material for applications where low-cost and portability are critically important. This review focuses on recent developments in iPAD technology as it applies specifically to making chemical measurements in the time range of October 2012 to October 2014. During this time over 1 000 articles have been published in the field, making a full comprehensive review citing all papers impossible. As a result, we seek to highlight the papers we find to be most impactful for the field. We also limited our search criteria and resulting discussion to papers describing analytical measurements. In recent years, paper as a substrate material has been used more frequently for electronics as evidenced by a number of excellent reviews. While many of these reports have bearing and importance to analytical measurements, they are not discussed here in interest of maintaining focus. The same is true of lateral flow immunoassays. Lateral flow immunoassays warrant a separate review based on their ubiquity and have been covered recently. Finally, searches were done using a combination of Google Scholar, Web of Science, PubMed, and SciFinder. In addition, high impact journals were scanned for manuscripts that did not readily appear with standard search terms. Despite these extensive searches, we have, without a doubt, missed many excellent papers relating to paper microfluidics. For those papers missed, we apologize in advance. [Description provided by NIOSH]
• Subjects:
  Chemistry Chemistry, Analytic Enzymes Food Contamination Occupational Health Safety
• Keywords:
  Analytical-chemistry Analytical-instruments Chemical-analysis Chemical-properties Electrochemical-properties Electrochemical-reactions Enzymatic-effects Food-contaminants Nanotechnology Paper-chromatography
• ISSN:
  0003-2700
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  19-41
• Volume:
  87
• Issue:
  1
• NIOSHTIC Number:
  nn:20046749
• Citation:
  Anal Chem 2015 Jan; 87(1):19-41
• Contact Point Address:
  Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523
• Email:
  Chuck.Henry@colostate.edu
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of Colorado, Denver
• Peer Reviewed:
  True
• Start Date:
  20070701
• Source Full Name:
  Analytical Chemistry
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:50f63028f9d994a36c2ead1ea45548630d37297ba8c9d8636ce35f6936bf253af67bb05348fced55fdf0d5957ef6550b5b1ea66f1ea00e4cac0ec78e58543aa3
• Download URL:
  https://stacks.cdc.gov/view/cdc/202081/cdc_202081_DS1.pdf
• File Type:
  [PDF - 1.95 MB ]