Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension

Details

• Personal Author:
  Arvapalli R ; Blough ER ; Dornon L ; Hamlekhan A ; He K ; Kolli MB ; Ma JY ; Manne NDPK ; Nalabotu SK ; Nandyala G ; Para R ; Rice KM ; Shokuhfar T ; Wehner PS
• Description:
  Cerium oxide (CeO2) nanoparticles have been posited to exhibit potent anti-oxidant activity which may allow for the use of these materials in biomedical applications. Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Sprague Dawley rats were randomly divided into three groups: control, MCT only (60 mg/kg), or MCT + CeO2 nanoparticle treatment (60 mg/kg; 0.1 mg/kg). Compared to the control group, the RV weight to body weight ratio was 45% and 22% higher in the MCT and MCT + CeO2 groups, respectively (p < 0.05). Doppler echocardiography demonstrated that CeO2 nanoparticle treatment attenuated monocrotaline-induced changes in pulmonary flow and RV wall thickness. Paralleling these changes in cardiac function, CeO2 nanoparticle treatment also diminished MCT-induced increases in right ventricular (RV) cardiomyocyte cross sectional area, ß-myosin heavy chain, fibronectin expression, protein nitrosylation, protein carbonylation and cardiac superoxide levels. These changes with treatment were accompanied by a decrease in the ratio of Bax/Bcl2, diminished caspase-3 activation and reduction in serum inflammatory markers. Taken together, these data suggest that CeO2 nanoparticle administration may attenuate the hypertrophic response of the heart following PAH. [Description provided by NIOSH]
• Subjects:
  Animals Antioxidants Cardiovascular Diseases Cardiovascular System Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Cerium Oxide Nanoparticles Cardiopulmonary-function Cardiopulmonary-system Cerium-compounds Heart Hypertension Laboratory-animals Monocrotaline Nanotechnology Proteins Pulmonary-function Pulmonary-system Pulmonary-system-disorders Pulmonary Arterial Hypertension Right Ventricular Hypertrophy

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• ISSN:
  0142-9612
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  37
• NIOSHTIC Number:
  nn:20045149
• Citation:
  Biomaterials 2014 Dec; 35(37):9951-9962
• Contact Point Address:
  Eric R. Blough, Center for Diagnostic Nanosystems, Room 241R, Robert C. Byrd Biotechnology Science Center Building, Department of Pharmaceutical Science and Research, 1700 3rd Ave., Marshall University, Huntington, WV 25755-1090
• Email:
  blough@marshall.edu
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Biomaterials
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e6d72e89f43fee9a277519afa36d24940bab2b97a32c3af6ab989b10a5d9b2c68ed90d6f43ed5fd7fd25531391e7eb2f5b789c97449d2c61ede7f6ab85e8c16b
• Download URL:
  https://stacks.cdc.gov/view/cdc/200669/cdc_200669_DS1.pdf
• File Type:
  [PDF - 3.35 MB ]