Risk of altered immune function associated with expanding production and use of novel nanomaterials

Details

• Personal Author:
  Kagan VE ; Shvedova AA
• Description:
  Unique chemical and physical properties of novel nanomaterials may inimitably modulate innate and adaptive immune responses. Recognition of engineered nanomaterials (EN) by the immune system, our primary defense outpost against foreign invasion, is a critical point. Because recent evidence suggests that immune-competent cells may respond to nanoparticles in a similar manner as to viruses/bacteria, there are complex relationships between the infection process and inflammatory responses to nanoparticles resulting in potent effects of nanoparticles on pulmonary clearance of bacteria. Among the cross-talks triggered by ENs and bacterial pathogens is the activation of oxidative stress and its relationships with inflammatory response. Recognition of ENs with characteristic surface features by immune cells and the subsequent effects of thus activated oxidative burst on subsequent stages of inflammation may act as essential determinants of the early onset of the fibrosis in response to carbonaceous nanomaterials. Another aspect is a recently reported involvement of autophagy as an important defensive mechanism of eukaryotic cells against microbes. Elucidation of how EN impact recognition, and/or phagocytosis promises to be a fruitful area for better understanding of interactions of nanoparticles with the cells of innate immune system, particularly macrophages. However, with the burgeoning capabilities to manipulate structures at the nano-scale, employing this cellular machinery for predicting safety of nanoproducts is not fully explored. Use of computational and structural modeling approaches can be used to identify essential patterns in the nanoparticle-biomolecule interactions to predict immunomodulation, which could be used to develop novel strategies and tools to safe nanotechnology. [Description provided by NIOSH]
• Subjects:
  Bacterial Infections Cytology Fibrosis Immune System Lung Microbiology Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Bacteria Bacterial-infections Carbon-compounds Cell-alteration Cell-damage Cellular-function Cellular-reactions Cellular-structures Immune-reaction Immune-system Lung-fibrosis Microorganisms Molecular-biology Molecular-structure Nanotechnology Oxidative-processes Phagocytic-activity Pulmonary-clearance Respiratory-infections

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• ISBN:
  9789522615329
• Publisher:
  Finnish Institute of Occupational Health
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  14
• NIOSHTIC Number:
  nn:20046196
• Citation:
  SENN2015: International Congress on Safety of Engineered Nanoparticles and Nanotechnologies, April 12-15, 2015, Helsinki, Finland. Helsinki, Finland: Finnish Institute of Occupational Health, 2015 Apr; :14
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Mining
• Peer Reviewed:
  False
• Source Full Name:
  SENN2015: International Congress on Safety of Engineered Nanoparticles and Nanotechnologies, 12-15 April 2015, Helsinki, Finland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c69df3628bc895baebfe3ec384cc07334fe438030dd8de56564218d82c3a0caf68f6ae1ec97c87eb1e674a113d092981aa63c01137ee89d089b133ae19884c24
• Download URL:
  https://stacks.cdc.gov/view/cdc/201321/cdc_201321_DS1.pdf
• File Type:
  [PDF - 175.04 KB ]