Direct effects of carbon nanotubes on dendritic cells induce immune suppression upon pulmonary exposure

Details

• Personal Author:
  Fadeel B ; Kagan VE ; Kisin ER ; Murray AR ; Shurin GV ; Shurin MR ; Shvedova AA ; Star A ; Tkach AV ; Young SH
• Description:
  Pharyngeal aspiration of single-walled carbon nanotubes (SWCNTs) caused inflammation, pulmonary damage, and an altered cytokine network in the lung. Local inflammatory response in vivo was accompanied by modified systemic immunity as documented by decreased proliferation of splenic T cells. Preincubation of naive T cells in vitro with SWCNT-treated dendritic cells reduced proliferation of T cells. Our data suggest that in vivo exposure to SWCNT modifies systemic immunity by modulating dendritic cell function. [Description provided by NIOSH]
• Subjects:
  Cytology Immune System Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Dendritic Cells Cell-alteration Cell-damage Cellular-function Cellular-reactions Immune-reaction Immune-system Immune System Immunosuppression In-vitro-study In-vivo-study Lung-cells Lung-disorders Lung-tissue Nanoparticles Nanotechnology Nanotubes Pulmonary-function Pulmonary-system Pulmonary-system-disorders

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• ISSN:
  1936-0851
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• Issue:
  7
• NIOSHTIC Number:
  nn:20038985
• Citation:
  ACS Nano 2011 Jun; 5(7):5755-5762
• Contact Point Address:
  Alexey V. Tkach, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  ats1@cdc.gov
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  ACS Nano
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:95b2dd4e036e8133da759a02ab9fc61a2e90594cc87a1331c2217e803459d67396510541250d853049f6f96db437c24c298ef65e769a2613e7e9794932f53b93
• Download URL:
  https://stacks.cdc.gov/view/cdc/192491/cdc_192491_DS1.pdf
• File Type:
  [PDF - 4.61 MB ]