Allergic airway inflammation is differentially exacerbated by daytime and nighttime ultrafine and submicron fine ambient particles: heme oxygenase-1 as an indicator of PM-mediated allergic inflammation

Details

• Personal Author:
  Bein KJ ; Carosino CM ; Castañeda AR ; Pinkerton KE ; Plummer LE ; Wexler AS ; Zhao Y
• Description:
  Ambient particulate matter (PM) originates from a range of sources and differs in composition with respect to season, time of day, and particle size. In this study, ambient PM samples in the ultrafine and submicrometer fine range were tested for the potential to exacerbate a murine model of allergic airway inflammation when exposure occurs solely during allergic sensitization, but not during subsequent allergen challenge. Temporally resolved and size-segregated PM samples were used to understand how summer or winter, day or night, and ambient ultrafine and submicrometer fine particle size influence PM's ability to exacerbate allergic inflammation. PM was collected in urban Fresno, CA. BALB/c mice were exposed to PM and house dust mite allergen (HDM) via intranasal aspiration on d 1, 3, and 5. HDM challenge occurred on d 12-14, with inflammation assessed 24 h following final challenge. While season or particle size did not predict allergic inflammation, daytime ultrafine and submicrometer fine particles significantly increased total cellular inflammation, specifically lymphocyte and eosinophil infiltration, compared to allergic controls. Further studies examined PM-mediated changes within the lung during the period where allergen sensitization occurred by measuring direct effects of PM on pulmonary oxidative stress and inflammation. Pulmonary levels of heme oxygenase-1 (HO-1), a biomarker of oxidative stress, but not cellular inflammation, demonstrated a remarkable correlation with the degree of allergic inflammation in animals sensitized to allergen and PM concomitantly, suggesting acute PM-mediated HO-1 levels may serve as a predictive indicator of a particle's ability to exacerbate allergic airway inflammation. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biomarkers Blood Environmental Monitoring Hypersensitivity Immune System Lung Occupational Health Particulate Matter Respiratory System Safety

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• Keywords:
  Air-samples Airborne-particles Allergens Allergic-reactions Allergies Exposure-assessment Immune-reaction Lung-function Lymphocytes Oxidative-processes Particulates Seasonal-factors Sensitization

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• ISSN:
  1528-7394
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  254-266
• Volume:
  78
• Issue:
  4
• NIOSHTIC Number:
  nn:20046074
• Citation:
  J Toxicol Environ Health A 2015 Feb; 78(4):254-266
• Contact Point Address:
  Kent E. Pinkerton, PhD, Center for Health and the Environment, Old Davis Road, University of California - Davis, Davis, CA 95616
• Email:
  kepinkerton@ucdavis.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f36c7beb8f36ef3af9544af6e079e02df4d617bef12d5cce9b2dbdd5df0c6d392b349c9cccc0d3c3bcf93bca3d4fc042abc2fec86991d31faef7b459aa0350ee
• Download URL:
  https://stacks.cdc.gov/view/cdc/201247/cdc_201247_DS1.pdf
• File Type:
  [PDF - 386.70 KB ]