Long-term health experience of jet engine manufacturing workers: III. Incidence of malignant central nervous system neoplasms

Details

• Personal Author:
  Buchanich JM ; Cunningham MA ; Esmen NA ; Fleissner ML ; Hancock RP ; Kennedy KJ ; Lacey SE ; Lieberman FS ; Marsh GM ; Youk AO
• Description:
  Objective: To explore a perceived unusual occurrence of glioblastoma at one jet engine manufacturing facility located in North Haven (NH), Connecticut (CT). Methods: Subjects were 212,513 workers ever employed in 1 of 8 manufacturing facilities from 1952 to 2001 and at risk from 1976 to 2004. We identified 722 cases of CNS neoplasms mainly by tracing through 19 state cancer registries. We computed standardized incidence ratios (SIRs) based on CT state and national rates and modeled internal relative risks (RRs). Results: We found overall deficits in cases for glioblastoma (275 cases, SIR = 0.77, CI = 0.68-0.87) and most other histology categories examined. NH workers had a not statistically significant overall 8% excess in glioblastoma (43 cases, SIR = 1.08, CI = 0.78-1.46). Salaried NH workers had a statistically significant twofold risk of glioblastoma compared with hourly workers (17 cases, RR = 2.04, CI = 1.15-3.57). Other subgroups of NH workers revealed elevated but not statistically significant glioblastoma risks but little evidence of an association with duration of employment or time since first employment. Conclusions: Incidence rates for glioblastoma and other malignant CNS neoplasm histologies were not elevated in the total cohort. The glioblastoma excesses observed among NH workers may reflect external occupational factors, non-occupational factors or workplace factors unique to NH unmeasured in the current study. [Description provided by NIOSH]
• Subjects:
  Aircraft Air Pollutants, Occupational Men Neoplasms Nervous System Nervous System Diseases Nervous System Disorders Occupational Health Risk Assessment Risk Factors Safety Women

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• Keywords:
  Aircraft-engines Author Keywords: Cancer Incidence Cancer Central-nervous-system-disorders Central Nervous System Neoplasms Cohort Study Emission-sources Exposure-levels Fumes Humans Jet Engine Manufacturing Nervous-system Nervous-system-disorders Nervous-system-function Risk-factors Statistical-analysis

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• ISSN:
  0251-5350
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Illinois ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  123-141
• Volume:
  35
• Issue:
  2
• NIOSHTIC Number:
  nn:20045792
• Citation:
  Neuroepidemiology 2010 Aug; 35(2):123-141
• Contact Point Address:
  Gary M. Marsh, PhD, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
• Email:
  gmarsh@cobe.pitt.edu
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Neuroepidemiology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ee42c1a931496e312695089ef3f7df7a8dc21ce8e49bb5154c362055c3124043ef3a7d8ba48b04f90f793298437d5cd9c34e2d34e88928c0aa2a43ba8215920f
• Download URL:
  https://stacks.cdc.gov/view/cdc/201080/cdc_201080_DS1.pdf
• File Type:
  [PDF - 282.62 KB ]