Long-term health experience of jet engine manufacturing workers: V. Issues with the analysis of non-malignant central nervous system neoplasms

Details

• Personal Author:
  Buchanich JM ; Cunningham MA ; Esmen NA ; Fleissner ML ; Hancock RP ; Kennedy KJ ; Lacey SE ; Leiberman FS ; Marsh GM ; Youk AO
• Description:
  Objective: We attempted to examine non-malignant central nervous system (CNS) neoplasms incidence rates for workers at 8 jet engine manufacturing facilities in Connecticut. The objective of this manuscript is to describe difficulties encountered regarding these analyses to aid future studies. Methods: We traced the cohort for incident cases of CNS neoplasms in states where 95% of deaths in the total cohort occurred. We used external and internal analyses in an attempt to obtain the true risk of non-malignant CNS in the cohort. Because these analyses were limited by data constraints, we conducted sensitivity analyses, including using state driver's license data to adjust person-year stop dates to help minimize underascertainment and more accurately determine cohort risk estimates. Results: We identified 3 unanticipated challenges: case identification, determination of population-based cancer incidence rates, and handling of case underascertainment. These factors precluded an accurate assessment of non-malignant CNS neoplasm incidence risks in this occupational epidemiology study. Conclusions: The relatively recent (2004) mandate of capturing non-malignant CNS tumor data at the state level means that, in time, it may be possible to conduct external analyses of these data. Meanwhile, similar occupational epidemiology studies may be limited to descriptive analysis of the non-malignant CNS case characteristics. [Description provided by NIOSH]
• Subjects:
  Aircraft Epidemiology Mortality Neoplasms Nervous System Nervous System Disorders Occupational Health Safety
• Keywords:
  Aircraft-engines Aircraft-parts-and-auxiliary-equipment Author Keywords: Cancer Incidence Cancer Cancer-rates Central-nervous-system-disorders Central Nervous System Neoplasms Cohort Study Jet Engine Manufacturing Mortality-data Mortality-rates Mortality-surveys Statistical-analysis

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• ISSN:
  1945-6123
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Illinois ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  115-119
• Volume:
  38
• Issue:
  3
• NIOSHTIC Number:
  nn:20045596
• Citation:
  J Registry Manag 2011 Autumn; 38(3):115-119
• Contact Point Address:
  Jeanine M. Buchanich, PhD, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
• Email:
  jeanine@cobe.pitt.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Registry Management
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:65f3c07cb4f5bccf92680b848e14db9a8fff7a363fa2907d409252c42c4f1a249cb3db408f1d2bfcf18a52eae80c12ce2b4b610021f88845f992eaa66fa99f68
• Download URL:
  https://stacks.cdc.gov/view/cdc/200957/cdc_200957_DS1.pdf
• File Type:
  [PDF - 435.47 KB ]