Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data

Details

• Personal Author:
  Buchanich JM ; Cunningham MA ; Esmen NA ; Fleissner ML ; Hancock R ; Kennedy KJ ; Lacey SE ; Lieberman FS ; Marsh GM ; Youk AO
• Description:
  Purpose: To compare ascertainment of central nervous system (CNS) neoplasms with the use of mortality and incidence data as part of an occupational epidemiology study. Methods: Deaths were identified by matching the cohort of 223,894 jet engine manufacturing employees to the U.S. Social Security Administration death files and the National Death Index. Incident cancer cases were identified by matching the cohort to 19 state cancer registries. Results: We identified 718 cases overall: 59% by the use of both mortality and cancer incidence tracing; 24% by the use of only mortality tracing, and 17% by the use of only cancer incidence tracing. Compared with state cancer registries, death certificates missed 38% of the malignant, more than six times the benign and nearly 1.5 times the unspecified CNS cases. The positive predictive value of death certificates, with cancer registry as gold standard, was 6% for unspecified, 35% for benign, and 86% for malignant histologies. Conclusions: Death certificates seriously underascertained benign and unspecified CNS tumors; analyses determined with mortality data would not accurately capture the true extent of disease among the cohort. Most state cancer registries have only collected nonmalignant CNS tumor information since 2004, which currently limits the usefulness of state cancer registries as a source of nonmalignant CNS tumor identification. Underascertainment of CNS deaths could seriously affect interpretation of results, more so if examining nonmalignant CNS. [Description provided by NIOSH]
• Subjects:
  Aircraft Epidemiology Mortality Neoplasms Nervous System Nervous System Disorders Occupational Health Safety
• Keywords:
  Aircraft-engines Aircraft-parts-and-auxiliary-equipment Author Keywords: Brain Cancer Cancer Cancer-rates Cancer Incidence Central-nervous-system-disorders Central Nervous System Neoplasms Death Certificates Methodology Mortality-data Mortality-rates Mortality-surveys Statistical-analysis

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• ISSN:
  1047-2797
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Illinois ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  10
• NIOSHTIC Number:
  nn:20045586
• Citation:
  Ann Epidemiol 2010 Oct; 20(10):759-765
• Contact Point Address:
  Jeanine M. Buchanich, PhD, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
• Email:
  jeanine@pitt.edu
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Epidemiology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c16cb31931f51db23768542e382cd936774943d07bbcb57abfd169890aa44a3cea46c8776eabf71d74babe5c2ac843dd8ece4c89429fc6e262779fb0c181330f
• Download URL:
  https://stacks.cdc.gov/view/cdc/200955/cdc_200955_DS1.pdf
• File Type:
  [PDF - 202.81 KB ]