Changes in the Metabolome and microRNA Levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study

Details

• Personal Author:
  Aschner M ; Calligaro D ; Cuevas E ; Ferguson S ; Gong B ; Hanig JP ; He Z ; Herr D ; Imam SZ ; Lantz SM ; Liachenko S ; MacMillan D ; Miller D ; MJ Kallman ; O'Callaghan J ; Pardo ID ; Paule MG ; Pierson JB ; Raymick J ; Roberts R ; Robinson B ; Rosas-Hernandez H ; Sarkar S ; Slikker W Jr. ; Smith A ; Somps C ; Tong W
• Description:
  Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at present, data on their expression and translation are lacking or inconsistent. In this pilot study using a trimethyl tin rat model of central nervous system toxicity, we have applied state-of-the-art assessment techniques to identify potential individual biomarkers and patterns of biomarkers in serum, plasma, urine or cerebral spinal fluid that may be indicative of nerve cell damage and degeneration. Overall changes in metabolites and microRNAs were observed in biological fluids that were associated with neurotoxic damage induced by trimethyl tin. Behavioral changes and magnetic resonance imaging T2 relaxation and ventricle volume changes served to identify animals that responded to the adverse effects of trimethyl tin. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Chemistry Energy Metabolism Environmental Exposure Hazardous Substances Laboratories Nervous System Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Author Keywords: Bioimaging Biological Factors Brain Cell Damage Central Nervous System Chemical Properties Chemicals Drugs Exposure Levels Fluids Laboratory Animals Magnetic Resonance Imaging Metabolites MRI Nerve Damage Neurobiology Neurotoxic Effects Neurotoxicity Neurotoxicology Risk Factors Sampling Toxins Translational

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• ISSN:
  1535-3702
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Arkansas ; Connecticut ; District of Columbia ; Indiana ; Maryland ; New York ; North Carolina ; OSHA Region 1 ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  228-236
• Volume:
  243
• Issue:
  3
• NIOSHTIC Number:
  nn:20050663
• Citation:
  Exp Biol Med 2018 Feb; 243(3):228-236
• Contact Point Address:
  Syed Z Imam, Division of Neurotoxicology, US FDA, NCTR, Jefferson, AR 72079, USA
• Email:
  Syed.Imam@fda.hhs.gov
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Experimental Biology and Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4072f00d0809a64ceaa53e90a5cdd00c9f54047ac3d1b66b2aa9f76b6c6d045c4586823b2b37fa42e534554a48ae7554a4c6d0f1c49536816d2ca947088c0443
• Download URL:
  https://stacks.cdc.gov/view/cdc/210916/cdc_210916_DS1.pdf
• File Type:
  [PDF - 538.21 KB ]