Determinants of progression in idiopathic pulmonary fibrosis

Details

• Personal Author:
  Burmeister LF ; Davis CS ; Dayton CS ; Helmers RA ; Hunninghake GW ; Schwartz DA ; Van Fossen DS
• Description:
  Idiopathic pulmonary fibrosis (IPF) is a progressive form of lung disease with a median survival of less than 5 yr. To address the progressive nature of this disease process, we investigated the determinants of decrements in lung function in patients with IPF. We prospectively evaluated 39 subjects with IPF. Our study subjects were followed for an average of 2 yr (range, 49 to 1,883 days) and lung function was measured on at least two separate occasions (mean = 9.1 separate tests) during the follow-up period. Since IPF is characterized by reduced lung volume and abnormal gas exchange, our analysis focused on the determinants of total lung capacity (TLC) and diffusing capacity of carbon monoxide (DLCO) during the period of observation. Although, on average, there was a 5.3% increase in the TLC and a 9.8% increase in DLCO between the first and last measure of lung function, 25% of the study population experienced a decline in the TLC and 28% of the study population experienced a decline in the DLCO. Decrements in TLC were independently associated with severe dyspnea (p = 0.01) and treatment with cyclophosphamide (p = 0.03). Decrements in DLCO were significantly and independently associated with more pack-years of cigarette smoking (p = 0.02), moderate (p = 0.03) or severe (p = 0.02) dyspnea, and treatment with cyclophosphamide (p = 0.0002). These findings indicate that several clinical characteristics are independently associated with subsequent declines in TLC and DLCO in patients with IPF. [Description provided by NIOSH]
• Subjects:
  Aging Epidemiology Fibrosis Lung Lung Diseases Men Morbidity Mortality Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Smokers Women

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• Keywords:
  Age-groups Diseases Humans Lung-disease Lung-disorders Lung-fibrosis Lung-function Morbidity-rates Mortality-rates Physiology Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Risk-factors Smoking Spirometry

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• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  444-449
• Volume:
  149
• Issue:
  2
• NIOSHTIC Number:
  nn:20044962
• Citation:
  Am J Respir Crit Care Med 1994 Feb; 149(2)(Pt 1):444-449
• Contact Point Address:
  David A. Schwartz, M.D., M.P.H., Pulmonary DiseaseDivision, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242
• Federal Fiscal Year:
  1994
• Performing Organization:
  University of Iowa, Iowa City, Iowa
• Peer Reviewed:
  True
• Part Number:
  1
• Start Date:
  19900701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  19930630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f48cd898a7f95ce23e38f84b5c8bbb92a227090f624cf38a2509b75ea5099157b9c148853ccf908f1db8d4ec454184a2e617b1e2654e8686ebffc86c30ceb94
• Download URL:
  https://stacks.cdc.gov/view/cdc/200539/cdc_200539_DS1.pdf
• File Type:
  [PDF - 746.77 KB ]