Urinary bisphenol A concentrations and cytochrome P450 19 A1 (Cyp19) gene expression in ovarian granulosa cells: an in vivo human study

Details

• Personal Author:
  Calafat, Antonia M. ; Ehrlich S ; Flaws JA ; Hauser R ; Missmer SA ; Peretz J ; Williams PL
• Description:
  BACKGROUND: Exposure to bisphenol A (BPA), a chemical widely used in consumer products, has been associated with in vitro Cyp19 gene expression. OBJECTIVE: To evaluate an in vivo human model of Cyp19 gene expression in granulosa cells. STUDY DESIGN: A subset of an ongoing prospective cohort study of women undergoing in vitro fertilization (IVF) at Massachusetts General Hospital. METHODS: Mixed effect models were used to evaluate the association of urinary BPA concentrations with granulosa cell Cyp19 mRNA expression. RESULTS: In 61 women undergoing 76 IVF cycles, adjusted changes in mean Cyp19 expression (beta estimate (95% CI)) for quartiles 2, 3 and 4 as compared to the lowest quartile were: -0.97 (-2.22, 0.28); -0.97 (-2.18, 0.24) and -0.38 (-1.58, 0.82). CONCLUSIONS: An in vivo model for evaluation of Cyp19 gene expression was developed for use in epidemiologic studies. In this pilot study, we found no statistically significant linear association between urinary BPA concentrations and Cyp19 expression. [Description provided by NIOSH]
• Subjects:
  Cytology Genetics Hazardous Substances Occupational Health Phenol Safety Toxicology Urine Urogenital System Women
• Keywords:
  Analytical-models Author Keywords: Bisphenol A Cell-function Cell-metabolism Cellular-reactions Cyp19 Fertility Follicular Fluid Gene Expression Genes Human Humans In-vivo-study Models Ovary Granulosa Cells P450 Aromatase Phenols Reproductive-system Ribonucleic-acids Statistical-analysis Toxic-materials Urinalysis

  More +
• ISSN:
  0890-6238
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18-23
• Volume:
  42
• NIOSHTIC Number:
  nn:20044684
• Citation:
  Reprod Toxicol 2013 Dec; 42:18-23
• Contact Point Address:
  Russ Hauser, Harvard School of Public Health, 665 Huntington Avenue, Building I, 14th Floor, Boston, MA 02115, USA
• Email:
  rhauser@hsph.harvard.edu
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7)
• Federal Fiscal Year:
  2014
• Performing Organization:
  Harvard University, School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Reproductive Toxicology
• End Date:
  20090630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e47c53c03fd75925753a3e3389619f6eebd497f125781e510c734058e4700da997af08365b3af8a0a7860573de028abcf30b49dc3b0ce1aff3da2c10004167e5
• Download URL:
  https://stacks.cdc.gov/view/cdc/200329/cdc_200329_DS1.pdf
• File Type:
  [PDF - 709.42 KB ]