Urinary Bisphenol A Concentrations and Implantation Failure among Women Undergoing in Vitro Fertilization

Details

• Journal Article:
  Environmental Health Perspectives
• Personal Author:
  Berry, Katharine F. ; Calafat, Antonia M. ; Ehrlich, Shelley ; Flaws, Jodi A. ; Hauser, Russ ; Missmer, Stacey A. ; Petrozza, John C. ; Williams, Paige L. ; Wright, Diane ; Ye, Xiaoyun
• Description:
  BACKGROUND: Bisphenol A (BPA) is a synthetic chemical widely used in the production of polycarbonate plastic and epoxy resins found in numerous consumer products. In experimental animals, BPA increases embryo implantation failure and reduces litter size. OBJECTIVE: We evaluated the association of urinary BPA concentrations with implantation failure among women undergoing in vitro fertilization (IVF). METHODS: We used online solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry to measure urinary BPA concentrations in 137 women in a prospective cohort study among women undergoing IVF at the Massachusetts General Hospital Fertility Center in Boston, Massachusetts. We used logistic regression to evaluate the association of cycle-specific urinary BPA concentrations with implantation failure, accounting for correlation among multiple IVF cycles in the same woman using generalized estimating equations. Implantation failure was defined as a negative serum ß-human chorionic gonadotropin test (ß-hCG < 6 IU/L) 17 days after egg retrieval. RESULTS: Among 137 women undergoing 180 IVF cycles, urinary BPA concentrations had a geometric mean (SD) of 1.53 (2.22) µg/L. Overall, 42% (n = 75) of the IVF cycles resulted in implantation failure. In adjusted models, there was an increased odds of implantation failure with higher quartiles of urinary BPA concentrations {odds ratio (OR) 1.02 [95% confidence interval (CI): 0.35, 2.95}, 1.60 (95% CI: 0.70, 3.78), and 2.11 (95% CI: 0.84, 5.31) for quartiles 2, 3, and 4, respectively, compared with the lowest quartile (p-trend = 0.06). CONCLUSION: There was a positive linear dose-response association between BPA urinary concentrations and implantation failure. [Description provided by NIOSH]
• Subjects:
  Benzhydryl Compounds Bisphenol A Embryo Implantation Epidemiology Epoxy Resins Fertility Fertilization In Vitro Infertility Occupational Health Phenol Phenols Plastics Pregnancy Reproduction Safety Urine Urogenital System Women

  More +
• Keywords:
  Author Keywords: Bisphenol A; Embryo Implantation; Fertility; Human; Reproduction; Women Plastics; Resins; Pregnancy; Epidemiology; Humans; Women; Urinalysis; In-vitro-studies; Fertility; Statistical-analysis; Phenols;
• Source:
  Environ Health Perspect 2012 Jul; 120(7):978-983
• ISSN:
  0091-6765
• Pubmed ID:
  22484414
• Pubmed Central ID:
  PMC3404656
• Document Type:
  Text
• Funding:
  ES000002/ES/NIEHS NIH HHS/United States ; ES009718/ES/NIEHS NIH HHS/United States ; OH008578/OH/NIOSH CDC HHS/United States ; R01 ES009718/ES/NIEHS NIH HHS/United States
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Illinois ; Massachusetts ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  6 pdf pages
• Volume:
  120
• Issue:
  7
• NIOSHTIC Number:
  nn:20041751
• Contact Point Address:
  R. Hauser, Harvard School of Public Health, 665 Huntington Ave., Building I, 14th Floor, Boston, MA 02115
• Email:
  rhauser@hsph.harvard.edu
• CAS Registry Number:
  2,2-Bis(4-hydroxyphenyl)propane (CAS RN 80-05-7) ; Phenol (CAS RN 108-95-2)
• Federal Fiscal Year:
  2012
• Performing Organization:
  Harvard University, School of Public Health, Boston, Massachusetts
• Peer Reviewed:
  True
• Collection(s):
  National Institute for Occupational Safety and Health CDC Public Access
• Main Document Checksum:
  urn:sha-512:fed5f7f030843d4cad1afcdd99ffbeb4b4e4354673aaf99cf445bdb3e57c54a59d8ebf4cdfeb6913b0e4c9245c6a311297c6be8d30ee9965920806f308121419
• Download URL:
  https://stacks.cdc.gov/view/cdc/10859/cdc_10859_DS1.pdf
• File Type:
  [PDF - 298.56 KB ]