Induction of stemlike cells with fibrogenic properties by carbon nanotubes and its role in fibrogenesis

Details

• Personal Author:
  Ammer AG ; Castranova, Vincent ; Luanpitpong S ; Manke A ; Martin KH ; Rojanasakul YI ; Wang L ; Yang Y
• Description:
  We developed a three-dimensional fibroblastic nodule model for fibrogenicity testing of nanomaterials and investigated the role of fibroblast stemlike cells (FSCs) in the fibrogenic process. We showed that carbon nanotubes (CNTs) induced fibroblastic nodule formation in primary human lung fibroblast cultures resembling the fibroblastic foci in clinical fibrosis and promoted FSCs that are highly fibrogenic and a potential driving force of fibrogenesis. This study provides a predictive 3D model and mechanistic insight on CNT fibrogenesis. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Lung Lung Diseases Men Occupational Health Respiratory System Respiratory Tract Diseases Safety Women
• Keywords:
  Author Keywords: Carbon Nanotubes Cell-cultures Cell-function Cellular-function Fibroblastic Nodules Fibrogenesis Fibrogenicity Humans Lung-disease Lung-function Lung Fibrosis Models Nanotechnology Side Population Stem-like Fibroblasts

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• ISSN:
  1530-6984
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  6
• NIOSHTIC Number:
  nn:20044642
• Citation:
  Nano Lett 2014 Jun; 14(6):3110-3116
• Contact Point Address:
  Yon Rojansakul, Pharmaceutical and Pharmacological Sciences Program, West Virginia University, Morgantown, West Virginia 26506
• Email:
  yrojan@hsc.wvu.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nano Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b17f1cfe92646df0938c85b829aaa8f668e4443af693c56f70093e9ae4a6219d753f087207151188f3131e4337cb5baa1faa1810c27d0a86bc0ad5e24c95fa08
• Download URL:
  https://stacks.cdc.gov/view/cdc/200303/cdc_200303_DS1.pdf
• File Type:
  [PDF - 5.43 MB ]