Occupational exposure to extremely low frequency magnetic fields and brain tumour risks in the INTEROCC study

Details

• Personal Author:
  Benke G ; Bowman, Joseph D. ; Cardis E ; Figuerola J ; Fleming S ; Hours M ; Kincl, Laurel ; Krewski D ; McLean D ; Parent M-E ; Richardson L ; Sadetzki S ; Schlaefer K ; Schlehofer B ; Schuz J ; Siemiatycki J ; Turner MC ; Van Tongeren M
• Description:
  Background: Occupational exposure to extremely low frequency magnetic fields (ELF) is a suspected risk factor for brain tumours, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure may be associated with specific histologic types of brain tumours. This study examines the association between ELF and brain tumours in the large-scale INTEROCC study. Methods: Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix assigned. Estimates of cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime, and 1-4, 5-9, and 10+ years prior to the diagnosis/reference date. Results: There were 3,761 included brain tumour cases (1,939 glioma, 1,822 meningioma) and 5,404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1-4 years prior to the diagnosis/reference date and glioma (odds ratio (OR) >/= 90th percentile vs < 25th percentile = 1.67, 95% confidence interval (CI) 1.36-2.07, p < 0.0001 linear trend), and, somewhat weaker associations with meningioma (OR >/= 90th percentile vs < 25th percentile = 1.23, 95% CI 0.97-1.57, p = 0.02 linear trend). Conclusions: Results showed positive associations between ELF in the recent past and glioma. Impact: Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumourigenesis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Electromagnetic Phenomena Environmental Monitoring Epidemiology Magnetic Fields Neoplasms Nervous System Nervous System Diseases Occupational Exposure Occupational Health Radiation Safety

  More +
• Keywords:
  Author Keywords: Extremely Low Frequency Magnetic Fields Biological-effects Brain-tumors Case-control Study Chemical-deposition Electromagnetic-fields Exposure-assessment Glioma Ionizing-radiation Job-analysis Magnetic-fields Magnetic-properties Meningioma Occupation Occupational-exposure Occupations Synergism Tumorigenesis Tumors

  More +
• ISSN:
  1055-9965
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; Oregon ; OSHA Region 10 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  23
• Issue:
  9
• NIOSHTIC Number:
  nn:20044630
• Citation:
  Cancer Epidemiol Biomark Prev 2014 Sep; 23(9):1863-1872
• Contact Point Address:
  Michelle C. Turner, CREAL-Centre for Research in Environmental Epidemiology, Parc de Recerca Biomèdica de Barcelona, Doctor Aiguader, 88 | 08003 Barcelona Spain
• Email:
  mturner@creal.cat
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing ; Services
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:de97b4c8c6cf5e5198289a2802616aebf7e6b42b5b4ff47014b231d2b8e01d30da136f7a16542647ce96ac4c81d0709e6cb2af6efd554716b789246b4b8b5528
• Download URL:
  https://stacks.cdc.gov/view/cdc/200296/cdc_200296_DS1.pdf
• File Type:
  [PDF - 408.68 KB ]