Interactions between occupational exposures to extremely low frequency magnetic field and chemicals for brain tumour risk in the INTEROCC study

Details

• Personal Author:
  Benke G ; Bowman, Joseph D. ; Cardis E ; Figuerola-Alquezar J ; Fleming S ; Hours M ; Kincl, Laurel ; Krewski D ; Lavoue J ; McLean D ; Parent ME ; Richardson L ; Sadetzki S ; Schlaefer K ; Schlehofer B ; Siemiatycki J ; Turner MC ; Van Tongeren M
• Description:
  Objectives: Brain tumors are a serious, often highly disease with few established risk factors. Although ionizing radiation has been clearly linked with brain tumors, there are a number of other environmental and occupational agents suspected. There may also be interactions between occupational agents for brain tumors however the epidemiological literature is sparse. Only one previous epidemiological study examined potential interactive effects between occupational exposure to extremely low frequency magnetic fields (ELF-MF) and chemical agents with various interactive effects observed. The objective of this paper was to examine the possible joint effects of occupational agents for brain tumors (specifically glioma and meningioma) including occupational ELF-MF and chemicals in the large-scale INTEROCC study. Methods: The INTEROCC study is formed by seven participating countries (Australia, Canada, France, Germany, Israel, New Zealand, United Kingdom) from the parent INTERPHONE study. Cases of primary brain glioma and meningioma aged at least 20 years were recruited between 2000 and 2004. Detailed occupational history data was collected for jobs held at least six months. Job titles were coded into standard international occupational classifications and estimates of ELF-MF and chemical exposure were assigned based on job exposure matrices. Odds ratios (and 95% confidence intervals) for single and joint occupational exposures were calculated according to a common reference category. Interactions on both the additive and multiplicative scale were assessed. Results: Data on a total of 3,978 brain tumor cases, including 2,054 gliomas and 1,924 meningiomas, were analysed with 5,601 control subjects. A number of interactions were observed, varying according to exposure time window, exposure metric, and included subjects. Results also varied according to tumour type. Conclusion: Interactions between occupational agents for brain tumors were observed however further research examining possible joint effects of occupational agents for brain tumours with refined assessments of occupational exposure in other large-scale studies is warranted. [Description provided by NIOSH]
• Subjects:
  Electromagnetic Phenomena Environmental Monitoring Epidemiology Magnetic Fields Neoplasms Nervous System Nervous System Diseases Occupational Exposure Occupational Health Radiation Safety

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• Keywords:
  Biological-effects Brain-tumors Chemical-deposition Electromagnetic-fields Exposure-assessment Ionizing-radiation Job-analysis Magnetic-fields Magnetic-properties Occupational-exposure Occupations Synergism

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; Oregon ; OSHA Region 10 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  70
• NIOSHTIC Number:
  nn:20043331
• Citation:
  Occup Environ Med 2013 Sep; 70(Suppl 1):A34-A35
• Federal Fiscal Year:
  2013
• NORA Priority Area:
  Services
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Medicine. 23rd Conference on Epidemiology in Occupational Health EPICOH 2013: Improving the Impact June 18-21, 2013, Utrecht, The Netherlands
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cd71d65e65bc4c3eafbf764f4f8c17575d36bf057263a50021f6bbc04728b249d533098a217c94c40a53ab0ccf7a936b5c23b32997f2885068c6526b1ba638c1
• Download URL:
  https://stacks.cdc.gov/view/cdc/195254/cdc_195254_DS1.pdf
• File Type:
  [PDF - 74.20 KB ]