Arsenic Carcinogenicity: Relevance of C-Src Activation

Details

• Personal Author:
  Luster MI ; Simeonova PP
• Description:
  Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder and respiratory tract cancers. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. One of this pathways might include c-Src dependent EGFR and MAPK activation. [Description provided by NIOSH]
• Subjects:
  Arsenic Carcinogens Environmental Exposure Genetics Inorganic Chemicals Neoplasms Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Skin Skin Diseases Urogenital Diseases Urogenital System

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• Keywords:
  Arsenic-compounds Author Keywords: Gene Expression Bladder-cancer Bladder Cancer Carcinogenicity Cell-growth Environmental-exposure Genes Kidneys Liver Occupational-exposure Reactive Oxygen Species Respiratory-system-disorders Skin-cancer Skin Cancer Tumors

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  277-282
• Volume:
  234
• Issue:
  1
• NIOSHTIC Number:
  nn:20022966
• Citation:
  Mol Cell Biochem 2002 May-Jun; 234-235(1-2):277-282
• Contact Point Address:
  P.P. Simeonova, NIOSH; HELD; TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888, USA
• Email:
  phs9@cdc.gov
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5ce315f71f47c683076338870c67a5d8625bab839e5f4cbd9767c777b3250e2ba63c336155f9684fde89810744cfb7ec5538ea2212dacb73886b633195db5cd4
• Download URL:
  https://stacks.cdc.gov/view/cdc/199568/cdc_199568_DS1.pdf
• File Type:
  [PDF - 62.39 KB ]