Mechanisms of Arsenic Carcinogenicity: Genetic or Epigenetic Mechanisms?

Luster MI; Simeonova PP

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Mechanisms of Arsenic Carcinogenicity: Genetic or Epigenetic Mechanisms?

Public Domain

2000/07/01
By Luster MI ; Simeonova PP

Details

Personal Author:

Luster MI ; Simeonova PP
Description:

Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic carcinogenesis have not been established. Arsenic does not act through classic genotoxic and mutagenic mechanisms, as do other metals such as cadmium or chromium. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. [Description provided by NIOSH]
Subjects:

Carcinogens Environmental Exposure Genetics Neoplasms Occupational Exposure Occupational Health Respiratory Tract Diseases Risk Assessment Risk Factors Safety Skin Skin Diseases
Keywords:

Arsenates Arsenic Compounds Author Keywords: Gene Expression Bladder Cancer Carcinogenesis Carcinogenicity Cell Growth Environmental Exposure Genes Occupational Exposure Reactive Oxygen Species Respiratory System Disorders Risk Analysis Risk Factors Skin Cancer
ISSN:

0731-8898
Document Type:

Text
Genre:

Journal Article
Place as Subject:

OSHA Region 3 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

281-286
Volume:

19
Issue:

3
NIOSHTIC Number:

nn:20020811
Citation:

J Environ Pathol Toxicol Oncol 2000 Jul-Sep; 19(3):281-286
Contact Point Address:

Petia P. Simeonova, NIOSH, HELD, TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888
Email:

phs9@cdc.gov
CAS Registry Number:

Arsenic (CAS RN 7440-38-2)
Federal Fiscal Year:

2000
Peer Reviewed:

True
Source Full Name:

Journal of Environmental Pathology, Toxicology, and Oncology
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:328be7a57d0ee5b1e3acde649d90499cb83c3dcd2769bc092e5340ef9ec20df40644b3ee4ee33cda9110dc04521c1d5e1430766c6235144132925a191614554e
Download URL:

https://stacks.cdc.gov/view/cdc/198476/cdc_198476_DS1.pdf
File Type:

[PDF - 211.54 KB ]

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