Mechanisms of Arsenic Carcinogenicity: Genetic or Epigenetic Mechanisms?

Details

• Personal Author:
  Luster MI ; Simeonova PP
• Description:
  Environmental and occupational exposure to arsenic is associated with increased risk of skin, urinary bladder, and respiratory tract cancers. The mechanisms responsible for arsenic carcinogenesis have not been established. Arsenic does not act through classic genotoxic and mutagenic mechanisms, as do other metals such as cadmium or chromium. Increasing evidence indicates that arsenic acts at the level of tumor promotion by modulating the signaling pathways responsible for cell growth. Description provided by NIOSH
• Subjects:
  • Carcinogens
  • Environmental Exposure
  • Genetics
  • Neoplasms
  • Occupational Exposure
  • Occupational Health
  • Respiratory Tract Diseases
  • Risk Assessment
  • Risk Factors
  • Safety
  More +
• Keywords:
  • Arsenic compounds
  • Arsenates
  • Carcinogenesis
  • Carcinogenicity
  • Carcinogens
  • Occupational exposure
  • Environmental exposure
  • Skin cancer
  • Respiratory system disorders
  • Bladder cancer
  More +
• ISSN:
  0731-8898
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  281-286
• Volume:
  19
• Issue:
  3
• NIOSHTIC Number:
  nn:20020811
• Citation:
  J Environ Pathol Toxicol Oncol 2000 Jul-Sep; 19(3):281-286
• Contact Point Address:
  Petia P. Simeonova, NIOSH, HELD, TMBB, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505-2888
• Email:
  phs9@cdc.gov
• CAS Registry Number:
  • Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology, Toxicology, and Oncology
• Download URL:
  https://stacks.cdc.gov/view/cdc/198476/cdc_198476_DS1.pdf
• File Type:
  [PDF - 211.54 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:328be7a57d0ee5b1e3acde649d90499cb83c3dcd2769bc092e5340ef9ec20df40644b3ee4ee33cda9110dc04521c1d5e1430766c6235144132925a191614554e