Evaluation of Allergen Sensitivity by Skin Prick Testing and Specific IgE in Asthmatic Children and Matched Controls in a Rural Cohort

Details

• Personal Author:
  Kelly KM ; Merchant, James A. ; Metwali N ; Stromquist A ; Thorne PS
• Description:
  The prevalence of childhood asthma has been increasing markedly in both urban and rural populations. We studied 100 rural asthmatic Iowa children and matched controls, ages 13.4+-3.3, in order to establish risk factors for allergy and asthma. In this analysis, we compared skin prick testing (SPT) with allergen-specific IgE (slgE) ELISA to determine if future studies could rely on serum analyses alone Fewer than 4% of subjects were SPT positive for corn smut, grain smut, mixed molds, mixed tree pollens, chicken feathers, horse, hog, cattle, dog, and soybeans. Greater than 4% were positive for house dust mites, cat, cockroach, mixed weed and mixed grass pollens. Among asthma cases, Sage positivist was as follows: 31-34% for house dust mites (Der f 1 and Der p 1),24% for cockroaches, 24% for cat hair, and 6% for weed pollens. All except Der p 1 had significantly higher positivity among asthmatics. Analysis of total IgE and slgE was conducted on serum samples drawn concurrently with SPT. Total lgE levels were significantly higher in asthmatics than control subjects (p=0.01). Among asthma cases, slgE positivity was as follows: 31-32% for house dust mites (Der p 1 and Der f 1), 18% for cockroaches, 36% for Fel d 1, 32% for weed pollens, 29% for Asp f 1 and 18% for mixed tree pollens. Concordance between SPT and slgE positivity for the six allergens common to both was 84- 90%. Conclusion: These data suggest that serum analysis may provide sufficient information on allergy in children such that researchers need not perform SPT. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Occupational Health Respiratory Tract Diseases Safety Skin
• Keywords:
  Allergens Allergic-reactions Allergies Children Pulmonary-system-disorders Respiratory-system-disorders Serological-techniques Serology Skin-tests
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Iowa ; Maryland ; OSHA Region 3 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• Issue:
  8
• NIOSHTIC Number:
  nn:20022919
• Citation:
  Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A127
• Federal Fiscal Year:
  2002
• Performing Organization:
  College of Public Health, University of Iowa, Iowa City, Iowa
• Peer Reviewed:
  False
• Start Date:
  19970930
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
• Supplement:
  Suppl
• End Date:
  20000929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cbd243f66b0f30728fca5bfa4c930ed332f048a061670e726e06fddc2eded53d9f2d8df48be31b32b882e9dd7a77208a7905dedc85f8fc103417acbf0dfbb397
• Download URL:
  https://stacks.cdc.gov/view/cdc/199533/cdc_199533_DS1.pdf
• File Type:
  [PDF - 137.33 KB ]