Effect of Follow-Up Time on Risk Estimates: A Longitudinal Examination of the Relative Risks of Leukemia and Multiple Myeloma in a Rubber Hydrochloride Cohort

Details

• Personal Author:
  Cooper SP ; Hornung, Richard W. ; Lai D ; Rinsky RA ; Silver, Sharon R.
• Description:
  Choice of follow-up time for an occupational cohort can influence risk estimates. We examined the effects of follow-up time on relative risk estimates for leukemia and multiple myeloma in a cohort of 1,845 rubber hydrochloride workers. We generated standardized mortality ratios (SMRs) for yearly follow-ups, beginning each study in 1940 and increasing study end dates from 1950 through 1996. We used Cox proportional hazards modeling to explore the effects of follow-up time on the exposure-response relationship. The SMR for leukemia rose to 13.55 in 1961 and fell nearly monotonically to 2.47 by 1996. Cox modeling suggested interaction between cumulative exposure and time since exposure. A longer time to peak risk was seen for multiple myeloma. Because summary risk estimates change with follow-up time, exposure limits set using these estimates may not adequately protect workers. Consideration of appropriate follow-up time and use of more complex temporal models are critical to the risk assessment process. [Description provided by NIOSH]
• Subjects:
  Benzene Blood Epidemiology Mortality Occupational Exposure Occupational Health Risk Assessment Risk Factors Rubber Safety Workplace

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• Keywords:
  Author Keywords: Risk Estimates Benzene Benzenes Follow-up Time Leukemia Leukemogenesis Mortality-data Mortality-rates Occupational-exposure Risk-analysis Risk-factors Risk Analysis Rubber-workers Rubber Workers Temporal Changes Worker-health Workplace-monitoring

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  481-489
• Volume:
  42
• Issue:
  6
• NIOSHTIC Number:
  nn:20022388
• Citation:
  Am J Ind Med 2002 Dec; 42(6):481-489
• Contact Point Address:
  National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies,4676 Columbia Parkway,MS R-44, Cincinnati,OH 45226, USA
• Email:
  ZRE4@cdc.gov
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c483dabde029288f2f053bb2fff87fcdb19f2f5a58b9d380abf2c5542cfafda281c67a624ed381c24f76f7644f16a796f3759f54566fc7dbba5e929b37407f43
• Download URL:
  https://stacks.cdc.gov/view/cdc/199184/cdc_199184_DS1.pdf
• File Type:
  [PDF - 128.59 KB ]