Benzene Exposure and Hematopoietic Mortality: A Long-Term Epidemiologic Risk Assessment

Details

• Personal Author:
  Hornung, Richard W. ; Rinsky RA ; Silver, Sharon R. ; Tseng, Chih-Yu
• Description:
  Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996. We evaluated risk using standardized mortality ratios (SMR) and generalized Cox proportional hazards regression models. Five new leukemia cases were observed in benzene-exposed white males, but the summary SMR for this group declined from 3.37 (95% CI = 1.54-6.41) to 2.56 (95% CI = 1.43-4.22). In regression models, cumulative exposure was significantly associated with elevated relative risks for leukemia mortality. Four new multiple myeloma deaths occurred, three of which were in workers judged to be unexposed. These findings reaffirm the leukemogenic effects of benzene exposure and suggest that excess risk diminishes with time. [Description provided by NIOSH]
• Subjects:
  Benzene Blood Epidemiology Mortality Occupational Exposure Occupational Health Risk Assessment Risk Factors Rubber Safety Workplace

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• Keywords:
  Author Keywords: Benzene Benzenes Leukemia Leukemogenesis Mortality-data Mortality-rates Multiple Myeloma Occupational-exposure Occupational Health Risk-analysis Risk-factors Risk Analysis Rubber-workers Rubber Workers Worker-health Workplace-monitoring

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• ISSN:
  0271-3586
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  474-480
• Volume:
  42
• Issue:
  6
• NIOSHTIC Number:
  nn:20022389
• Citation:
  Am J Ind Med 2002 Dec; 42(6):474-480
• Contact Point Address:
  National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, MS R-44, Cincinnati, OH 45226, USA
• Email:
  Robert.Rinsky@chmcc.org
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1739cee961c86bb1455bc93aae4ae8dad5318096dc33de64f7eaa1333bfa0ef5cd8e0fa3c88fc302ceae8abaab9282aa3a86d6c898cd45ac501c41d01f7d5edf
• Download URL:
  https://stacks.cdc.gov/view/cdc/199185/cdc_199185_DS1.pdf
• File Type:
  [PDF - 113.07 KB ]