Intracellular Signal Transduction of Cells in Response to Carcinogenic Metals

Details

• Personal Author:
  Chen F ; Shi X
• Description:
  Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, nickel, and others. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of the carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on carcinogenic metal-induced signal transduction pathways leading to the activation of NF-kappaB, cell apoptosis and cell cycle progression, three crucial steps or events involved in the transformation and carcinogenesis. This review summarizes current knowledge and our recent studies concerning intracellular signal transduction pathways initiated by carcinogenic metals and the cross-talk that occurs among these pathways in cells in response to metals. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Genetics Metals Occupational Health Safety
• Keywords:
  Animal-studies Apoptosis Author Keywords: Metal Carcinogenesis Cell-alteration Cell-growth Cell-transformation Cell Cycle Genes In-vitro-studies In-vivo-studies Metal-compounds NF-kB Signal Transduction

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• ISSN:
  1040-8428
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  105-121
• Volume:
  42
• Issue:
  1
• NIOSHTIC Number:
  nn:20022254
• Citation:
  Crit Rec Oncol Hematol 2002 Apr; 42(1):105-121
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  lfd3@cdc.gov
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Arsenic trioxide (CAS RN 1327-53-3) ; Chromic trioxide (CAS RN 1333-82-0) ; Chromium (CAS RN 7440-47-3) ; Cobalt (CAS RN 7440-48-4) ; Copper (CAS RN 7440-50-8) ; Nickel (CAS RN 7440-02-0) ; Vanadium oxide (V2O3) (CAS RN 1314-34-7) ; Vanadium oxide (V2O5) (CAS RN 1314-62-1)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Critical Reviews in Oncology Hematology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7cbf94b713f39cc38a8fbcd679709eee32e7254765ca5a4c534cd2586a3e15bd990cafaa8a82c4026fb793ccf9c50ffe1eea730771a30aaaae0428dfbf92c8de
• Download URL:
  https://stacks.cdc.gov/view/cdc/199090/cdc_199090_DS1.pdf
• File Type:
  [PDF - 349.57 KB ]