New Perspectives in Arsenic-Induced Cell Signal Transduction

Details

• Personal Author:
  Castranova, Vincent ; Qian Y ; Shi X
• Description:
  Although the carcinogenicity of arsenic has been well established, the underlying molecular mechanisms have not yet been fully identified. Accumulating evidence indicates that the alteration of cellular signal transduction is directly related to the carcinogenesis of arsenic. This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-B activation, cell cycle arrest, and apoptosis. [Description provided by NIOSH]
• Subjects:
  Arsenic Carcinogens Inorganic Chemicals Metals Occupational Health Safety
• Keywords:
  Apoptosis Arsenic Arsenic-compounds Author Keywords: Metal Carcinogenesis Carcinogenicity Cell-alteration Cell-damage Cell Cycle Cellular-reactions MAPK Metal-compounds NF-kB Reactive Oxygen Species Tyrosine Phosphorylation

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• ISSN:
  0162-0134
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  271-278
• Volume:
  96
• Issue:
  2
• NIOSHTIC Number:
  nn:20023370
• Citation:
  J Inorg Biochem 2003 Aug; 96(2-3):271-278
• Contact Point Address:
  Yong-Qian, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  yqian@cdc.gov
• Federal Fiscal Year:
  2003
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Inorganic Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fc7d5d0f9402af02f2a65d5f1f5e136c78ee91f96d3e03265e452a5d511c128db5a69032a63d5a26fffb8c4bfa02d9ec8ca6b4ef3f182925fed197d780c7c292
• Download URL:
  https://stacks.cdc.gov/view/cdc/195843/cdc_195843_DS1.pdf
• File Type:
  [PDF - 118.21 KB ]