Carcinogenic Metals and NF-kB Activation

Details

• Personal Author:
  Castranova, Vincent ; Chen F ; Ding M ; Shi X
• Description:
  Epidemiological and animal studies suggest that several metals and metal-containing compounds are potent mutagens and carcinogens. These metals include chromium, arsenic, vanadium, and nickel. During the last two decades, chemical and cellular studies have contributed enormously to our understanding of the mechanisms of metal-induced pathophysiological processes. Although each of these metals is unique in its mechanism of action, some common signaling molecules, such as reactive oxygen species (ROS), may be shared by many of these carcinogenic metals. New techniques are now available to reveal the mechanisms of carcinogenesis in precise molecular terms. In this review, we focused our attentions on metal-induced signal transduction pathways leading to the activation of NF-kappaB, a transcription factor governing the expression of most early response genes involved in a number of human diseases. [Description provided by NIOSH]
• Subjects:
  Animals Arsenic Carcinogens Chromium Epidemiology Inorganic Chemicals Metals Mutagens Nickel Occupational Health Safety Vanadium Compounds

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• Keywords:
  Animal-studies Arsenic-compounds Author Keywords: NF-kB Carcinogenesis Carcinogenicity Chromium-compounds IKK Metal-compounds Nickel-compounds ROS Signal Transduction Vanadium-compounds

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-171
• Volume:
  222
• Issue:
  1
• NIOSHTIC Number:
  nn:20021697
• Citation:
  Mol Cell Biochem 2001 Jun; 222(1-2):159-171
• Contact Point Address:
  Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Chromium (CAS RN 7440-47-3) ; Nickel (CAS RN 7440-02-0) ; Vanadium (CAS RN 7440-62-2)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2cddadb462cb9544f59a46b0b987f6bc6d616897859c9ba7c50829e7995715c5d2cc4142cbf753609c4e6cee66264d0119467f08b4bad6d2564254986c0a292
• Download URL:
  https://stacks.cdc.gov/view/cdc/198813/cdc_198813_DS1.pdf
• File Type:
  [PDF - 234.45 KB ]