Distribution of HER2 V655 Genotypes in Breast Cancer Cases and Controls in the United States

Details

• Personal Author:
  Keshava C ; Keshava N ; McCanlies EC ; Weston A ; Wolff MS
• Description:
  The minor variant frequency of a HER2 polymorphism (HER2(V655)) has been determined for 471 United States women enrolled in a multiracial case-control study. Allelic frequencies varied significantly by race. Genotypic distributions showed no excess breast cancer risk associated with inheritance of HER2(V655) either as carriers (OR=1.2, 95% CI=0.8-1.9), heterozygotes (OR=1.2, 95% CI=0.8-1.9), or homozygotes (OR=1.4, 95% CI=0.4-4.2). Nor was there a significant association when each racial group was considered separately. The current study suggests the HER2(V655) allele is not a breast cancer risk factor for Caucasians, African-Americans, or Latinas. [Description provided by NIOSH]
• Subjects:
  Case Reports Demography Epidemiology Neoplasms Occupational Health Race Factors Risk Assessment Risk Factors Safety Sex Characteristics
• Keywords:
  African-Americans Author Keywords: Breast Neoplasms Breast-cancer Cancer Case-studies Caucasians Controlled-environment Demographic-characteristics HER2 Latinas Polymorphisms Racial-factors Risk-analysis Risk-factors Sex-factors Statistical-analysis

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• ISSN:
  0304-3835
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  37-41
• Volume:
  173
• Issue:
  1
• NIOSHTIC Number:
  nn:20021770
• Citation:
  Cancer Lett 2001 Nov; 173(1):37-41
• Contact Point Address:
  Ainsley Weston, National Institute for Occupational Safety and Health - CDC, 1095 Willowdale Road, MS-L3014, Morgantown, WV 26505, USA
• Email:
  agw8@cdc.gov
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:69de77cbeaca24992b08a55313614f7333c171bb2a86f606941ebaf738b96c77615991b2710acf0196733955f458d6720a22316ba8c0e97904782d76b54a0dc4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198879/cdc_198879_DS1.pdf
• File Type:
  [PDF - 77.87 KB ]