Organochlorine Exposures and Breast Cancer Risk in New York City Women

Details

• Personal Author:
  Berkowitz GS ; Bleiweiss IJ ; Brower S ; Pace B ; Roy N ; Senie R ; Tartter P ; Wallenstein S ; Weston A ; Wolff MS
• Description:
  A hospital-based case-control study of breast cancer risk related to organochlorine (OC) exposure was conducted in a multiethnic setting in New York City. We enrolled 175 breast cancer patients and 355 control patients. The overall racial/ethnic distribution was 57% Caucasian, 21% Hispanic, 22% African-American; cases and controls were frequency-matched by age and race/ethnicity. Tumor markers (estrogen and progesterone receptors, p53, erbB-2) were assessed and organochlorines (DDE, DDT, trans-nonachlor, and higher (HPCB) and lower (LPCB) chlorinated biphenyls) were measured in blood serum. Tumors among minority women were of slightly higher stage than among Caucasians, but tumor markers were similar across the racial/ethnic groups. DDE levels were highest among African-American and Hispanic women; DDT was highest among Hispanics; HPCBs were highest among African-Americans; LPCBs were lowest among Hispanics; and trans-nonachlor was highest among African-Americans. However, OC levels were not associated with risk for breast cancer, nor did OCs differ with respect to tumor stage or tumor markers. Higher DDE levels were associated with increasing body mass index (BMI), but with decreasing level of education, frequency of nulliparity, and frequency of family history of breast cancer. HPCB levels decreased with BMI and were not correlated with breast cancer risk factors. These relationships can be attributed to historical patterns of exposure and to metabolic differences in OCs related to BMI. [Description provided by NIOSH]
• Subjects:
  Age Factors Case Reports Demography Environmental Exposure Neoplasms Occupational Health Race Factors Risk Assessment Risk Factors Safety Sex Characteristics

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• Keywords:
  Age Factors Author Keywords: Breast Cancer BMI Breast Cancer Cancer Case Studies DDT Demographic Characteristics Ethnic Exposure Assessment Exposure Levels Organochlorine Compounds PCB Racial Factors Risk Analysis Risk Factors Sex Factors Trans-nonachlor Tumors

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• ISSN:
  0013-9351
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-161
• Volume:
  84
• Issue:
  2
• NIOSHTIC Number:
  nn:20020861
• Citation:
  Environ Res 2000 Oct; 84(2):151-161
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:75c2dea8aa427ad32f4c904e1a136ecc80296460dd1b72aadb66d6940f938496832e9cbbc17f9d3a87b31a1a1e6a29b811f63cd9966fc89e793e81c5ecd21c7f
• Download URL:
  https://stacks.cdc.gov/view/cdc/198519/cdc_198519_DS1.pdf
• File Type:
  [PDF - 135.23 KB ]