Transactivation of RARE and GRE in the Cellular Response to Arsenic

Details

• Personal Author:
  Castranova, Vincent ; Costa M ; Ding M ; Huang C ; Ju G ; Li J ; Shi X ; Vallyathan V
• Description:
  Arsenic compounds are a somewhat unique class of metals, which have been considered as both carcinogens and chemotherapeutic agents for cancers. Tumor promotion effects of arsenic are believed to be associated with its transactivational activities on transcription factors, such as AP-1 and NFkappaB, while the induction of cell apoptosis and differentiation by arsenic is considered to be a mechanism for the chemotherapeutic effects of arsenic. Here, we found that exposure of cells to arsenite and arsenate leads to transactivation of retinoic acid response elements (RARE) and glucocorticoid response elements (GRE) in mouse epidermal JB6 cells. These inductions occur in a time-dependent manner. Furthermore, induction of RARE activity by arsenic was synergistically enhanced by co-treatment of cells with retinoic acid, while GRE activation by arsenic was not affected by combined treatment of cells with fluocinolone acetonide (FA). In consideration of the important role of RARE and GRE in induction of cell differentiation, we speculate that transactivation of RARE and GRE by arsenic may be involved in its induction of cell differentiation and anti-cancer activities in addition to its induction of apoptosis. [Description provided by NIOSH]
• Subjects:
  Animals Arsenic Carcinogens Environmental Monitoring Inorganic Chemicals Laboratories Metals Neoplasms Occupational Health Safety
• Keywords:
  Animal-studies Arsenates Arsenic-compounds Arsenites Author Keywords: Arsenic Cancer Cellular-reactions Exposure-assessment Exposure-levels GRE Laboratory-animals RARE Signal Transduction

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• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  119-125
• Volume:
  222
• Issue:
  1
• NIOSHTIC Number:
  nn:20021752
• Citation:
  Mol Cell Biochem 2001 Jun; 222(1-2):119-125
• Contact Point Address:
  Nelson Institute of Environmental Medicine, New York University School of Medicine, NY 10016
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Arsenite (CAS RN 15502-74-6)
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9eed1a01e9d3ecb2258761c01548ee6faf78b9edeb3fc7dddb3e75951cb7466f6351af936f965637c279700e953c10037c92b94259b96249f1dcbdc71d15fff7
• Download URL:
  https://stacks.cdc.gov/view/cdc/198861/cdc_198861_DS1.pdf
• File Type:
  [PDF - 88.67 KB ]