Cell Apoptosis Induced by Carcinogenic Metals

Castranova, Vincent; Chen F; Shi X; Vallyathan V

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Cell Apoptosis Induced by Carcinogenic Metals

Public Domain

2001/06/01
By Castranova, Vincent ; Chen F ; Shi X ; ...

Details

Personal Author:

Castranova, Vincent ; Chen F ; Shi X ; Vallyathan V
Description:

Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed. [Description provided by NIOSH]
Subjects:

Arsenic Carcinogens Chromium Environmental Exposure Hazardous Substances Inorganic Chemicals Metals Neoplasms Occupational Exposure Occupational Health Safety Vanadium Compounds
Keywords:

Arsenic-compounds Author Keywords: Apoptosis Cancer Carcinogenesis Chromium-compounds DNA Damage Environmental-exposure Metal Metal-compounds Occupational-exposure ROS Toxic-effects Toxins Vanadium-compounds
ISSN:

0300-8177
Document Type:

Text
Genre:

Journal Article
Place as Subject:

OSHA Region 3 ; West Virginia
CIO:

National Institute for Occupational Safety and Health (NIOSH)
Division:

HELD - Health Effects Laboratory Division
Topic:

Workplace Safety & Health
Location:

North America
Pages in Document:

183-188
Volume:

222
Issue:

1
NIOSHTIC Number:

nn:20021699
Citation:

Mol Cell Biochem 2001 Jun; 222(1-2):183-188
Contact Point Address:

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
CAS Registry Number:

Arsenic (CAS RN 7440-38-2) ; Chromium (CAS RN 7440-47-3) ; Vanadium (CAS RN 7440-62-2)
Federal Fiscal Year:

2001
Peer Reviewed:

True
Source Full Name:

Molecular and Cellular Biochemistry
Collection(s):

National Institute for Occupational Safety and Health
Main Document Checksum:

urn:sha-512:46e6314a78ff828a2dcc5f3c0c2c9b162a808749a718fd9f8630a48c60692aff460b577b4d6d732d703fd011011d1f08cdd92644958b72586d1cdbad88a15a4f
Download URL:

https://stacks.cdc.gov/view/cdc/198815/cdc_198815_DS1.pdf
File Type:

[PDF - 78.68 KB ]

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