Vanadium- and Chromium-Induced Cell Signal Transduction

Details

• Personal Author:
  Qian Y ; Shi X
• Description:
  Both vanadium and chromium are two common toxic metals. Accumulating evidence indicates that exposure of humans to either metal induces a wide spectrum of adverse effects, including carcinogencity. neurotoxicity. and immunotoxicity. Among these adverse effects, carcinogencity is the major geological consequence. The underlying molecular mechanisms have not been fully identified yet. For the past several years, much attention has been focused on how these two metals alter cellular signal transduction to lead to carcinogenesis. This chapter will serve as a summary of recent advances in the knowledge base for cellular signal transduction, including induction of tyrosine phosphorylation. phosphatidylinositol 3-kinase (PI3 kinase) signaling, nuclear factor-kB (NF-kB) activation, cell cycle arrest, and apoptosis,in response to vanadium or chrominum. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chromium Hazardous Substances Metals Nervous System Occupational Health Safety Vanadium Compounds
• Keywords:
  Carcinogenesis Carcinogenicity Cell-function Cellular-reactions Chromium-compounds Immunotoxins Neurotoxic-effects Neurotoxins Toxic-effects Toxic-materials Toxins Vanadium-compounds

  More +
• ISBN:
  9780824748746
• Publisher:
  Marcel Dekker
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  475-492
• Volume:
  187
• NIOSHTIC Number:
  nn:20024916
• Citation:
  Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease). Vallyathan V, Castranova V, Shi X, eds. New York: Marcel Dekker, 2004 Apr; 187:475-492
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Vanadium (CAS RN 7440-62-2)
• Editor(s):
  Vallyathan V; Castranova V; Shi X
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Source Full Name:
  Oxygen/nitrogen radicals: lung injury and disease (Lung biology in health and disease)
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0f124d728dd860099bb362af95e0330265a8f841bc0ac7883a95b2248745af7c3f1427a184aa68219dca2b9fa7929a2d39700c69bf6e99c1533edfda3e620ef5
• Download URL:
  https://stacks.cdc.gov/view/cdc/196494/cdc_196494_DS1.pdf
• File Type:
  [PDF - 3.87 MB ]