Neurochemical Correlates of Cognitive Deficits in Weanling Rats Exposed to Chlorpyrifos

Details

• Personal Author:
  Carter JC ; Jett DA ; O'Callaghan JP ; Schuh RA
• Description:
  Previous studies have shown that moderate to high levels of chlorpyrifos (CPF) alter cognitive function in adult and immature rats, probably related to the inhibition of acetylcholinesterase (AChe). We have previously reported on an alteration of cAMP signaling by CPF in rats exposed to moderate doses, and PC12 cells exposed to CPF at doses lower than those required to inhibit AChE. In the present study, we tested the hypothesis that the exposure to CPF during brain development causes deficits in cognitive function of weanling rats, and we determined the relationship between cognitive effects, AChE activity, muscarinic receptor binding, and the expression of the phosphorylated form of Ca2+/cAMP-dependent response element binding protein (pCREB). [Description provided by NIOSH]
• Subjects:
  Animals Cells, Cultured Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Cell-cultures Exposure-levels Exposure-methods Laboratory-animals Proteins
• ISSN:
  1096-6080
• Publisher:
  Oxford University Press
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Maryland ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  241-242
• Volume:
  60
• Issue:
  1
• NIOSHTIC Number:
  nn:20021439
• Citation:
  Toxicologist 2001 Mar; 60(1):241-242
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba9839c9e4f36f78cd1eed28fa6d1713b68719d4050cddc80c20a98ffa3156d4c6d769c28abfa860265c17f66351661fb869649f9f1dd6be1f78cbb72bee765a
• Download URL:
  https://stacks.cdc.gov/view/cdc/198753/cdc_198753_DS1.pdf
• File Type:
  [PDF - 205.33 KB ]