Mixture Component Effects on the Percutaneous Absorption of TCB, PCB, and PCP

Details

• Personal Author:
  Baynes RE ; Mumtaz M ; Pirone JR ; Qiao GL ; Riviere JE
• Description:
  Interactions between chemicals in a mixture and interactions of mixture components with the skin, can significantly alter the rate and extent of percutaneous absorption, as well as the cutaneous diposition of a xenobiotic. The predictive ability of dermal absorption models, and consequently, the dermal risk assessment process would be greatly improved through the elucidation and characterization of these interactions. As a first step, the effects of several generalized mixture components, on the percutaneous absorption of 3,3' ,4,4', 5-pentachloro biphenyl (PCB), 3,3',4,4'-tetrachloro biphenyl (3,3',4,4'-TCB), and pentachlorophenol (PCP) were examined using isolated perfused porcine skin flap (IPPSF) and porcine skin flow through (PSFT) diffusion cell systems. Mixtures containing combinations of the surfactant sodium lauryl sulfate (SLS), the vasodilator methyl nicotinate (MNA), ethanol, and water were studied. With all mixtures studied, PCB, and TCB absorption was negligible (approximately 0.1 % of the applied dose) as quantified using both radiolabel and an HPLC method. In contrast, the absorption of PCP occurred to a much greater extent (-14% of the applied dose), and showed significant mixture effects. Not only was the magnitude of PCP absorption altered, but the absorption profiles, and the disposition within the stratum corneum, dermis, epidermis, and subcutaneous fat were highly dependent on mixture components. The contrast of the results obtained for PCB and PCP, illustrate an area of interaction between the structural and chemical parameters that dictate the amount of chemical absorbed into the systemic circulation. [Description provided by NIOSH]
• Subjects:
  Biphenyl Compounds Chemistry Occupational Health Phenol Polychlorinated Biphenyls Safety Skin Skin Absorption
• Keywords:
  Absorption Rates Biphenyls Chemical Composition Chemical Properties Models Phenolic Compounds Phenols Polychlorinated-biphenyls Skin Absorption Skin Exposure
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Georgia ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  54
• Issue:
  1
• NIOSHTIC Number:
  nn:20021034
• Citation:
  Toxicologist 2000 Mar; 54(1):150
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3) ; Pentachlorophenol (CAS RN 87-86-5)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 39th Annual Meeting, March 19-23, 2000, Philadelphia, Pennsylvania
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3476122266dbe4eaa6cfe62a60e7b4b8e9aff29576938c12ac6657f7ee3fd4388dc2ca61308477b454e34585e37fdfe1e2035c5f4d18de1761eb6f82134065c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198614/cdc_198614_DS1.pdf
• File Type:
  [PDF - 151.38 KB ]