Dermal Absorption and Tissue Disposition of 3,3′, 4,4′-Tetrachlorobiphenyl (TCB) in an Ex-Vivo Pig Model: Assessing the Impact of Dermal Exposure Variables

Details

• Personal Author:
  Qiao GL ; Riviere JE
• Description:
  TCB is one of the dioxin-like polychlorinated biphenyls (PCBs). This research was designed to help assess the risk of occupational and environmental TCB exposure. To evaluate exposure variables' effects on dermal absorption and cutaneous disposition, 14C-TCB (40 microg/cm(2)) in acetone, methylene chloride, a water-acetone mixture, and a soil-based mixture were applied in an ex-vivo pig-skin-flap model (n = 4-5/treatment). Dermal absorption (0.11-0.66%, 8 hr) and penetration (1.14-2.48%) varied according to exposure conditions. Acetone and methylene chloride vehicles differed in absorption profiles and skin penetration patterns but were similar in absorption amounts. Adding water to the acetone did not change absorption but did alter the penetration pattern. The non-occluded soil-based mixture showed more absorption than did the liquid vehicles (p<0.05), but occlusion significantly (p<0.05) decreased that absorption (0.66->0.29%, 8 hr) and penetration (2.48->1.11%). In conclusion, dermal absorption data from liquid-organic or aqueousorganic mixtures may underestimate the risk of exposure to TCB-contaminated soil. [Description provided by NIOSH]
• Subjects:
  Biphenyl Compounds Occupational Health Polychlorinated Biphenyls Safety Skin Skin Absorption
• Keywords:
  Author Keywords: 3,3,4,4-tetrachloro Biphenyl Biphenyls Exposure Variables PCBs Percutaneous Absorption Pharmacodynamics Polychlorinated-biphenyls Polychlorinated Biphenyls Skin Skin Absorption Skin Exposure TCB

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• ISSN:
  1077-3525
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  127-137
• Volume:
  6
• Issue:
  2
• NIOSHTIC Number:
  nn:20020787
• Citation:
  Int J Occup Environ Health 2000 Apr-Jun; 6(2):127-137
• Contact Point Address:
  NIOSH, Centers for Disease Control, Morgantown, WV 26505-2888
• Email:
  gaq1@cdc.gov
• CAS Registry Number:
  PCB 77 (CAS RN 32598-13-3)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Occupational and Environmental Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9b0e66e1cea29d60520d73308df771975bb15b9fcf2798cea01fffc6ceb0cc39222d8a74760c277fbca1474acf5df2626af9dc5812c41d425945a8bc91c1eade
• Download URL:
  https://stacks.cdc.gov/view/cdc/198453/cdc_198453_DS1.pdf
• File Type:
  [PDF - 848.18 KB ]