Regression Method to Estimate Provisional TLV/WEEL-Equivalents for Non-Carcinogens

Details

• Personal Author:
  Attfield MD ; Bedillion EJ ; Quilong Y ; Walter KM ; Whaley DA
• Description:
  There is a huge and changing number of chemicals in commerce for which workplace exposure criteria have not been assigned. Assigning an exposure criterion by an expert committee is resource-intensive-not soon available for the large majority of chemicals in current use. In the absence of assigned criteria, we have provided a regression method to estimate a first-screen estimate of a 'TLV/WEEL-equivalent' inhalation time-weighted average exposure criterion for a pure chemical (or chemical group) from a measure of a non-stochastic toxic exposure to elicit a chronic or sub-chronic health effect, known as a lowest observable adverse effect level (LOAEL) or a (highest) no observable adverse effect level (NOAEL). Results are presented for six data sets for which both a threshold limit value (TLV) or workplace environmental exposure level (WEEL) exposure criterion is presently assigned, and a LOAEL or NOAEL measure of toxic health effect was available from the United States Environmental Protection Agency Integrated Risk Information System data base. The results can be applied as a first estimate of exposure to substances for which no TLV or WEEL (TLV/WEEL) exists, and also serve as a mechanism for identifying substances for potential re-evaluation of their exposure limit, based on their relative position about the prediction models. [Description provided by NIOSH]
• Subjects:
  Chemistry Occupational Health Risk Assessment Safety Workplace
• Keywords:
  Author Keywords: TLV Chemical Analysis Chemical Properties Exposure Assessment Exposure Criterion Exposure Limits Exposure Methods Models Regression Risk Analysis Threshold Limit Values Toxicity Estimates WEEL Work Analysis Workplace Monitoring Workplace Studies

  More +
• ISSN:
  0003-4878
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  361-374
• Volume:
  44
• Issue:
  5
• NIOSHTIC Number:
  nn:20020858
• Citation:
  Ann Occup Hyg 2000 Aug; 44(5):361-374
• Contact Point Address:
  David A. Whaley, Department of Industrial Management Systems Engineering, West Virginia University, P.O. Box 6070, Morgantown, WV 26506, USA
• Email:
  dwhaley@wvu.edu
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bb1c5543eb38648ed5f4ef6b116930110678b2ab8800189191a49565b942f693a05956dfe04ea1a4f19f0ed0a8c97f4d7fa950de6a8c2cebc772e857244b498e
• Download URL:
  https://stacks.cdc.gov/view/cdc/198516/cdc_198516_DS1.pdf
• File Type:
  [PDF - 254.86 KB ]