Studies on the Simultaneous Pharmacokinetic-Pharmacodynamic (PK-PD) Modeling of Xylazole in Sheep and Rabbits

Details

• Personal Author:
  Li J-C ; Li S-F ; Li T ; Liu X-H ; Liu Y-H ; Qiao G-L ; Yi H-B
• Description:
  The simultaneous pharmacokinetic-pharmacodynamic modeling of xylazole were studied by gas chromatography (GC), high-performance liquid chromatography (HPLC), spectrofluometry, radioimmunoassay, electroencephalography (EEG) and electromyography (EMG) method. The pharmacokinetic data were analyzed by GC-HPLC RIA method, and the pharmacodynamic data were measured by ECG, EEG and EMG method. The parameters of pharmacokinetic-pharmacodynamic simultaneous modeling were estimated by cpu-pk-pdcomputer program on the basis of changes of acetylcholine (Ach), norepinephrine (NE) and ß-Endorphin (ß-Ep) levels after intramuscular administration in blood, CSF, pituitary and hypothalamus. We explained their sedation analgesic and muscular relaxation effective mechanism and their interrelation. The sampling and effect-quanlity assay were simulcast on same animals. The parameter of simultaneous pharmacokinetic-pharmacodynamic modeling of xylazole as follows: A. Parameters of simultaneous PK-PD modeling for blood kinetics-EEG: N(Hill coefficient)=0.10123, Keo=0.2209 min -1 , t 12Keo =3.14 min, E c50 =0.304 µg/mL, Emax=0.2214(%), AUE 1=0.02427 µg/mL·min, AUE 2=0.2140 µg/mL·min, r=0.9926; B. Parameters of simultaneous PK-PD modeling for CSF kinetics-EEG: N=0.9766, Keo=0.2209 min -1 , t 12Keo =3.1378 min, E C50 =0.3954 µg/mL, Emax=0.2214(%), AUE 1=0.1605 µg/mL·min, AUE 2=0.1835 µg/mL·min, r=0.9937; C. Parameters of simultaneous PK-PD modeling for blook dinetics-EMG: N=0.1379,Keo=0.2265 min -1 , t 12Keo =3.0596 min, E c50 =0.7804 µg/mL, Emax=0.8721(%), AUE 1=0.5357 µg/mL·min, AUE 2=0.5584 µg/mL·min, r=0.9989. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Xylazole In Vivo Study Laboratory Animals Modeling Models Pharmacodynamics PK-PD Rabbit Sheep Simultaneous

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• ISSN:
  1004-7034
• Document Type:
  Text
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-6
• Volume:
  2000
• Issue:
  12
• NIOSHTIC Number:
  nn:20020733
• Citation:
  J Animal Sci Vet Med 2000 Dec; 2000(12):1-6
• CAS Registry Number:
  2-Thiazolamine, N-(2,6-dimethylphenyl)-, hydrochloride (1:1) (CAS RN 123941-49-1)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Heilongjiang Journal of Animal Science and Veterinary Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3274f00eaf13954c711d9fed4f4037f4f5512791db085b023c25d7356ca1931fa7a0c36e870c787b41a82bb7cf80152f2061952c1b66960df3ac2dff515244e1
• Download URL:
  https://stacks.cdc.gov/view/cdc/198406/cdc_198406_DS1.pdf
• File Type:
  [PDF - 477.13 KB ]