New Insights into the Role of Nuclear Factor-KB, a Ubiquitous Transcription Factor in the Initiation of Diseases

Details

• Personal Author:
  Castranova, Vincent ; Chen F ; Demers LM ; Shi X
• Description:
  Nuclear factor-B (NF-B) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-B is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases. [Description provided by NIOSH]
• Subjects:
  Carcinogens Genetics Neoplasms Occupational Health Safety
• Keywords:
  Cancer Cancer-rates Carcinogenesis Gene-mutation Genes Genetic-disorders Genetic-engineering Genetic-factors Heredity Statistical-analysis
• ISSN:
  0009-9147
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  7-17
• Volume:
  45
• Issue:
  1
• NIOSHTIC Number:
  nn:20027447
• Citation:
  Clin Chem 1999 Jan; 45(1):7-17
• Contact Point Address:
  Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
• Email:
  lfd3@cdc.gov
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Clinical Chemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:56d24ee48ed862f264fd098992853ab554ed7b69aafad2308beec7faee923b17f5cd58a704d320172766192d3979417f27daa4310831034d9146df7344507257
• Download URL:
  https://stacks.cdc.gov/view/cdc/197580/cdc_197580_DS1.pdf
• File Type:
  [PDF - 253.37 KB ]