Endogenous Inhibitors of Nuclear Factor-kB, an Opportunity for Cancer Control

Details

• Personal Author:
  Chen F
• Description:
  Excessive and prolonged activation of nuclear factor-B (NF-B) has been linked to numerous human diseases, especially cancer, because of the elevated expression of genes encoding antiapoptotic proteins, cytokines, chemokines, cell adhesion molecules, and so on. Eukaryotic cells have developed multiple mechanisms to keep this ubiquitous transcription factor in check. In addition to the inhibitor of B family proteins, a number of endogenous molecules that negatively regulate the activation or activity of NF-B have been identified. These molecules include A20, CYLD, cyPG15-deoxy-12,14-prostaglandin J2, Foxj1, Twist proteins, and ß-arrestins. The extended list of these endogenous inhibitors of NF-B may provide new opportunities for the development of novel strategies for the intervention of malignant transformation. The question to be asked is how NF-B is sustained activated in a number of cancers in which so many antagonists are surrounded. [Description provided by NIOSH]
• Subjects:
  Carcinogens Genetics Neoplasms Occupational Health Safety
• Keywords:
  Cancer Carcinogenesis Carcinogenicity Diseases Genes Genetic-disorders Genetic-factors Proteins
• ISSN:
  0008-5472
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  64
• Issue:
  22
• NIOSHTIC Number:
  nn:20025977
• Citation:
  Cancer Res 2004 Nov; 64(22):8135-8138
• Contact Point Address:
  Fei Chen, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  LFD3@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a12616fa47e3c4d3baa78b0e563a915de28f88cd7898756b99487934b3a8e7c143d38b68277179573dfa52947e88e13ffeddfb2efc82165b969fb0f031f4d339
• Download URL:
  https://stacks.cdc.gov/view/cdc/197128/cdc_197128_DS1.pdf
• File Type:
  [PDF - 259.83 KB ]