Dry Trimellitic Anhydride (TMA) Powder Dermal Sensitization Induces Specifice IgE and Airway Responses Following Challenge in Brown Norway Rats

Details

• Personal Author:
  Fedan, Jeffery S. ; Lewis, Daniel M. ; Siegel, Paul D. ; Zhang XD ; Fedan, Jeffery S. ; Lewis, Daniel M. ; Siegel, Paul D. ; Zhang XD
• Description:
  TMA is a low-molecular-weight chemical that can induce production of specific IgE and occupational asthma in sensitized individuals. The respiratory tract is considered to be the major exposure route leading to immunological sensitization, but dermal exposure also has the potential to induce TMA-sensitization. Our previous work demonstrated a dose-dependent production of specific IgE and airway response after TMA aerosol challenge in Brown Norway (BN) rats sensitized by overnight TMA (occluded) dermal exposure. IgE production and airway responses to inhaled TMA after repeated, short-term (5 hr) dermal exposures to dry TMA powder without occlusion were investigated in two groups of rats (n=8/group, dose: 40 mg or 4 mg) in the present study. Dermal exposures were performed on days 0, 7, 14 and 21. Sera were collected on days 0, 7, 14, 21, 28, 35 and positive IgE was found after 14 days. Rats were challenged by a 10 min, 40 mg/m3 TMA (nose-only) aerosol and respiratory physiology monitored on day 35 immediately following exposure in unrestrained rats using a whole body plethysmography system. Compared to non-sensitized rats, the two groups of sensitized BN rats displayed distinct early (EAR) and late airway responses (LAR), as noted by an increase in enhanced pause (Penh, an index of airway resistance). The EAR was noted immediately following the challenge and lasted approximately 0.5 to 1 hour. The LAR began 3 to 4 hours post-challenge durations ranging from 4 to 8 hours. This work demonstrates that dermal exposure to TMA powder can lead to immunological sensitization and obstructive airway responses on subsequent exposure to TMA aerosol. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Asthma Asthma, Occupational Immune System Irritants Laboratories Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Skin Skin Diseases

  More +
• Keywords:
  Animal-studies Bronchial-asthma Immunologic-disorders Laboratory-animals Occupational-exposure Occupational-hazards Occupational-health Respiratory-irritants Respiratory-system-disorders Skin-disorders Skin-exposure Skin-irritants

  More +
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  99
• NIOSHTIC Number:
  nn:20027262
• Citation:
  International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC. Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 2002 Sep; :99
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  International conference on occupational and environmental exposures of skin to chemicals: science and policy, September 8-11, 2002, Washington, DC
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3adbca4c04b441bfdfdd226d172fb3e7947b65b65f11d89a3b17ad5377914d2f0901b9c8f3756280702c10a96199f8f78ff4f82062ff634c87ab394818756c38
• Download URL:
  https://stacks.cdc.gov/view/cdc/197516/cdc_197516_DS1.pdf
• File Type:
  [PDF - 807.60 KB ]