Animal Models of Occupational Asthma: Tools for Understanding Disease Pathogenesis

Details

• Personal Author:
  Johnson VJ ; Luster MI
• Description:
  Occupational asthma is the most frequently reported occupational respiratory disease in industrialized nations, and numerous low-molecular-weight chemicals and high-molecular-weight proteins encountered in the workplace are known or suspected causative agents (1). Classical and novel animal models are being used to investigate exposure determinants, epitope identity, and the role played by the immune system in occupational asthma in order to recapitulate disease phenotype and further current understanding of its pathogenesis. Important aspects of exposure determinants that can be addressed and controlled using animal models include (i) relevant routes of exposure including respiratory and/or skin, (ii) exposure dose, (iii) exposure duration and frequency, and (iv) determination of relevant epitopes. In addition, well-defined genetics of animal models present unique opportunities for detailed investigations into pathogenic mechanisms through the use of transgenic models and antibody neutralization strategies. The data generated through the use of animal models is instrumental for risk assessment used to refine workplace exposure limits. Numerous guinea pig, rat, and mouse models of occupational asthma have been developed to address these issues. It is likely that key molecular and cellular events will be identified through the use of these models, potentially leading to new treatment modalities that may be specific for these classes of asthmogen and will aid in establishing more protective workplace exposure limits. [Description provided by NIOSH]
• Subjects:
  Animals Asthma Asthma, Occupational Environmental Monitoring Laboratories Occupational Diseases Occupational Exposure Occupational Health Respiratory Tract Diseases Safety Skin

  More +
• Keywords:
  Animal-studies Bronchial-asthma Diseases Exposure-assessment Exposure-levels Exposure-limits Laboratory-animals Models Occupational-diseases Occupational-exposure Occupational-hazards Occupational-health Pathogenesis Pathogenicity Respiratory-system-disorders Skin-exposure

  More +
• ISBN:
  9780824729776
• Publisher:
  Taylor & Francis Group
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  141-159
• NIOSHTIC Number:
  nn:20030020
• Citation:
  Asthma in the workplace and related conditions, third edition. Bernstein IL, Chan-Yeun M, Malo JL, Bernstein DI, eds. New York: Taylor and Francis Group, 2006 Jan; :141-159
• Editor(s):
  Bernstein IL; Chan-Yeung M; Malo JL; Bernstein DI
• Federal Fiscal Year:
  2006
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Asthma in the workplace and related conditions, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ee14da6b4ca7d5f3a9cb390bb70c6fc30404dd4953b55824b7afc0b7b3ee95d69d7f78cb8fafdf1cf527f040465a6c6cf7d0da67a366e642e739cd67fa72811
• Download URL:
  https://stacks.cdc.gov/view/cdc/190879/cdc_190879_DS1.pdf
• File Type:
  [PDF - 2.38 MB ]