Is NF-kappaB a Culprit in Type 2 Diabetes?

Details

• Personal Author:
  Chen F
• Description:
  It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis. [Description provided by NIOSH]
• Subjects:
  Endocrine System Endocrine System Diseases Genetics Occupational Health Safety
• Keywords:
  Author Keywords: IKKb Diabetes Endocrine-function Endocrine-system Endocrine-system-disorders Gene-mutation Genetic-factors Insulin Resistance NF-kB
• ISSN:
  0006-291X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-3
• Volume:
  332
• Issue:
  1
• NIOSHTIC Number:
  nn:20027080
• Citation:
  Biochem Biophys Res Commun 2005 Jun; 332(1):1-3
• Email:
  fchen@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Biochemical and Biophysical Research Communications
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a460480cc35d79de6e0b95cf479c55018c84afd5919a544bf5fcd9441bfdc17f6e54fb37d324fa3ed79a3fb5babc4ea7a23917c322efd91c32fc73b2710cfd71
• Download URL:
  https://stacks.cdc.gov/view/cdc/197452/cdc_197452_DS1.pdf
• File Type:
  [PDF - 103.87 KB ]