Genetic associations with sporadic neuroendocrine tumor risk

Details

• Personal Author:
  Asomaning K ; Bradbury PA ; Christiani, David C. ; De Vivo I ; Frauenhoffer CS ; Hooshmand SM ; Kulke MH ; Lin X ; Liu C-Y ; Liu G ; Paulus JK ; Su L ; Ter-Minassian M ; Wang Z ; Wu MC ; Zhai R
• Description:
  Genetic risk factors for sporadic neuroendocrine tumors (NET) are poorly understood. We tested risk associations in patients with sporadic NET and non-cancer controls, using a custom array containing 1536 single-nucleotide polymorphisms (SNPs) in 355 candidate genes. We identified 18 SNPs associated with NET risk at a P-value <0.01 in a discovery set of 261 cases and 319 controls. Two of these SNPs were found to be significantly associated with NET risk in an independent replication set of 235 cases and 113 controls, at a P value =0.05. An SNP in interleukin 12A (IL12A rs2243123), a gene implicated in inflammatory response, replicated with an adjusted odds ratio (95% confidence interval) (aOR) = 1.47 (1.03, 2.11) P-trend = 0.04. A second SNP in defender against cell death, (DAD1 rs8005354), a gene that modulates apoptosis, replicated at aOR = 1.43 (1.02, 2.02) P-trend = 0.04. Consistent with our observations, a pathway analysis, performed in the discovery set, suggested that genetic variation in inflammatory pathways or apoptosis pathways is associated with NET risk. Our findings support further investigation of the potential role of IL12A and DAD1 in the etiology of NET. [Description provided by NIOSH]
• Subjects:
  Aging Biological Factors Biomarkers Endocrine System Endocrine System Diseases Genetics Men Neoplasms Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Age-groups Biological-factors Biological-function Endocrine-function Endocrine-system Endocrine-system-disorders Genes Genetic-factors Humans Risk-factors Tumors

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• ISSN:
  0143-3334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  32
• Issue:
  8
• NIOSHTIC Number:
  nn:20039747
• Citation:
  Carcinogenesis 2011 Aug; 32(8):1216-1222
• Contact Point Address:
  Monica Ter-Minassian, Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115
• Email:
  mtermina@hsph.harvard.edu
• Federal Fiscal Year:
  2011
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Carcinogenesis
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc6284a1655c5eb3420a442ab3c6a6001bc115b5594dc57b45a5ec033e207c374bbc8d4bea3929cf64cb64aca66395a392fff0f735b123e352b449b0666d335d
• Download URL:
  https://stacks.cdc.gov/view/cdc/192867/cdc_192867_DS1.pdf
• File Type:
  [PDF - 125.77 KB ]