Gestational Exposure to PFOS Suppresses Immunological Function in F1 Mice

Details

• Personal Author:
  Butterworth L ; Keil DE ; Mehlman T ; Peden-Adams MM
• Description:
  Perfluorinated hydrocarbons have been manufactured for over 40 years and have numerous applications in industry. This group of compounds has recently generated much interest as common metabolites (i.e., perfluorooctane sulfonate (PFOS); perfluoroctanic acid (PFOA)) are found to be persistent in the environment, have been detected in blood samples of both wildlife and humans, and appear to have a common mechanism of action. Studies show that these perfluorinated compounds cause peroxisomal proliferation, hepatomegaly, altered steroidogenesis, and body weight decreases that are associated with a wasting syndrome; however, effects on immune function have not been extensively assessed. This study examined the immunotoxicological effects of PFOS on the developing immune system should exposure occur during pregnancy. Therefore, C57BL/6N pregnant dams (mated with C3H/HeJ males) were orally exposed with 0, 0.1, 1.0 or 5.0 mg/kg of PFOS during each day of gestation. F1 offspring were evaluated for immunological alterations at 4 and 8 weeks of age. In general, there were no treatment effects on body, spleen, or thymus mass, and limited effects on kidney and liver mass. Corresponding flow cytometric analysis of CD4/CD8 lymphocytic subpopulations in the thymus and spleen were not altered in 4- or 8-week F1 mice. However, assessment of functional immunological parameters at 8-weeks of age revealed functional deficits. Natural killer cell activity was dose-responsively suppressed in both male and female F1 adults, whereas IgM plaque forming cell (PFC) responses were only suppressed in male F1 adults. Our data indicate that prenatal exposure to PFOS can suppress functional immunological responses that are evident at adulthood, with increased vulnerability exhibited in the male F1 offspring. [Description provided by NIOSH]
• Subjects:
  Animals Blood Energy Metabolism Environmental Exposure Environmental Monitoring Hematologic Tests Hydrocarbons Immune System Laboratories Liver Occupational Health Safety Teratogenesis

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• Keywords:
  Animal-studies Blood-samples Environmental-exposure Exposure-assessment Exposure-levels Hepatotoxicity Hepatotoxins Immunologic-disorders Immunological-tests Immunology Immunotoxins Laboratory-animals Metabolites Teratogens Teratology

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; OSHA Region 4 ; South Carolina ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  84
• NIOSHTIC Number:
  nn:20026444
• Citation:
  Toxicologist 2005 Mar; 84(Suppl 1):180
• CAS Registry Number:
  Perfluorooctanoic acid (CAS RN 335-67-1)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 44th Annual Meeting and ToxExpo, March 6-10, 2005, New Orleans, Louisiana
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f346a301114b5597dba98a90a0ce7bbbce7189dbe9a0b4a20d141e22f290da256b41a83ab3245116969fcd24db0e8a00416eb5e1ef90ff3a207bc5c85515618e
• Download URL:
  https://stacks.cdc.gov/view/cdc/197285/cdc_197285_DS1.pdf
• File Type:
  [PDF - 327.09 KB ]